Neuropsychopharmacologia Hungarica

2009. június, XI. évfolyam 2. szám [translated version]

Review

SNAP-25: a novel candidate gene in psychiatric genetics

Reka Kovacs-Nagy, Jimmy Hu, Zsolt Ronai, Maria Sasvari-Szekely
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary

SNAP-25 (synaptosomal-associated protein of 25 kDa) is an integral part of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor), a docking complex for synaptic vesicle exocytosis and neurotransmitter release. Results with SNAP-25 deficient mouse models highly accelerated association studies of SNAP-25 as a candidate gene for psychiatric disorders, such as Attention Deficit Hyperactivity Disorder (ADHD) and Schizophrenia. Candidate gene studies implicate a large number of single nucleotide polymorphisms (SNPs). Among the numerous SNPs, the miR SNPs are novel functional variants affecting the binding of specific microRNA to their target mRNA. According to our in silico studies there are two putative miR SNPs in the 3'untranslated region (3'UTR) of the SNAP-25 gene. If the putative miR SNPs are shown to have a function in vivo their implication in further psychogenetic association studies will have a higher impact.

Keywords: SNAP-25, microRNA, psychiatric genetics, candidate gene study, ADHD, depression

 

Összefoglaló közlemény

SNAP-25: Egy új kandidáns gén a pszichiátriai genetikában

Kovács-Nagy Réka, Jimmy Hu, Rónai Zsolt, Sasvári-Székely Mária
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary