Volume 21, Issue 3, September 2019
Az antipszichotikum farmakoterápia egyik fontos kérdése, hogy milyen betegcsoportba tartozó páci-
enseinknek javasolunk és írunk fel ilyen hatású gyógyszert. A másik fontos tényező, hogy az általunk
javasolt kezeléssel mennyire együttműködő, illetve adherens a betegünk.
Cariprazine, a new type – dopamine D₃ receptor preferring – partial agonist atypical antipsychotic for the treatment of schizophrenia and the primary negative symptoms
István Laszlovszky, Béla Kiss, Ágota Barabássy, Margit Kapás és György Németh
Dopamine D₂ receptor partial agonists represent a new generation of atypical antipsychotics.
Cariprazine, which has received centralized market authorization from the European Medicines Agency in 2017 for the treatment of adult patients with schizophrenia (including those
with predominant negative symptoms of schizophrenia) differs from the other two partial
agonist antipsychotics aripiprazole and brexpiprazole due to its unique features. Cariprazine
is a dopamine D₃ preferring D₃/D₂ partial agonist with very similar dopamine receptor subtype selectivity as dopamine. It has proven efficacy in the treatment of positive and negative
symptoms of schizophrenia, as well as for relapse prevention. Further phase-3 clinical studies
proved the efficacy of cariprazine in the acute treatment of manic or mixed episodes associated with bipolar I disorder, as well as in bipolar depression. For the adjunctive treatment of
major depressive disorder, phase 3 studies are in progress.
Keywords: cariprazine, dopamine D₃ and D₂ receptor partial agonist, atypical antipsychotic,
schizophrenia, predominant negative symptoms
Psychotherapy endows a sense of control in patients gripped with emotional conflicts which allow them to handle their reflexes and regain composure through conscious and behavioral alterations. These transformational changes can be brought about by improving their listening skills, observational capacities, creating awareness, making them more attentive and intervening. Conventional psychotherapy calls for one-to-one sessions during treatment. Considering the increased access to information technology in our normal living, the thought of human interaction being replaced by IT tools came to existence. Specialized tools and techniques are employed through the course of therapy which not only alters but also accentuates their cognitive and effective understanding. The idea of amalgamating these two broad ambits – the complexities of psychology and dynamism of artificial intelligence has gained momentum in recent times. The previous reluctance of a few psychologists regarding inculcating expert systems into routine practice due to maybe employment-related insecurities or being swapped by a computer led to underutilization of the latent competence of using IT. Primarily, human behavior itself cannot be copied in totality by technology, and AI has a great deal to cover in this regards, but researchers are doing their best to deliver on these premises. Apart from this patient resistance to this encroachment of technology should also be looked at critically for gaining mass acceptance. This review focuses on how machine intelligence through computer-implemented psychotherapeutic tools can enhance self-awareness.
Forty years (1979–2019) of our working group in the service of Hungarian and international suicidology
Tamás Zonda, Borbála Paksi, Károly Bozsonyi, Előd Veres
In our study we have summarised the various fields of our suicide research made in the last
40 years. We have devided our whole publications into thematic chapters: cultural-history,
regional differences, follow-up studies, prenvention, ecological researches, mostly sociology.
Some of them had been firstly published in Hungarian or/and also in international literature.
We repeatedly reiterate the importance of writing a Hungarian suicide prevention program.
We agree with the opinion: “Suicide prevention is far more than a psychiatric business”.
Keywords: suicide, multidirectional researches, Hungary
There is a growing body of data on paternal peripartum depression (perinatal depression
in father; PND-F), however, it has traditionally been investigated only in women. Recently
accumulating results confirmed the prominent role of the mental health of fathers in the
psychosocial development of children and new trends showed up concerning the father’s role
in the family. In this case report we demonstrate the clinical aspect of a depressive episode of
a “stay-at-home” father of two children (a 5-year old boy living with autism and a 8-year old
girl). In relation to the case we want to emphasize that various situations can be stressful for a
person with affective vulnerability. It is noteworthy that although childcare is a happy period
for the majority, it can be a stressful life period for vulnerable persons and it can provoke
a depressive episode. Acceptance and tolerance of this correlation at the level of society is still
far away, however, it is indispensible for adequate and timely intervention which is essential
for the stability of families and the psychosocial development of children.
Keywords: peripartum depression; paternal depression; men’s depression; affective vulnerability; perinatal depression in fathers, PND-F