[et_pb_section fb_built=”1″ _builder_version=”3.22.3″ custom_padding=”28px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.25″ custom_padding=”27px|0px|0|0px|false|false”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ header_font=”||||||||” header_text_color=”#000000″ header_4_font=”|700||on|||||” header_4_text_align=”center” header_4_text_color=”#000000″ header_4_font_size=”19px” header_4_letter_spacing=”1px”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”3.22.3″ custom_padding=”24px|0px|25px|0px|false|false”][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”In Memoriam Dr. Kalma\u0301r Sa\u0301ndor” url=”https:\/\/mppt.hu\/magazin\/pdf\/vol21issue2\/nekrolog_honlapra.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/vol21issue2\/nekrolog_honlapra.pdf”]<\/p>\n
(1941\u20132019)<\/p>\n<\/div>\n<\/div>\n<\/div>\n
[\/et_pb_blurb][et_pb_blurb title=”Editoral in Hungarian ” url=”https:\/\/mppt.hu\/magazin\/pdf\/vol21issue2\/szerklev_honlapra.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/vol21issue2\/szerklev_honlapra.pdf” link_option_url_new_window=”on”]<\/p>\n
Addiktofo\u0301bia: a gyo\u0301gyszerre szoka\u0301sto\u0301l valo\u0301 fe\u0301lelem<\/strong> Laz\u00e1ry Judit<\/em><\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n A pszichia\u0301triai betegek ella\u0301ta\u0301sa sora\u0301n tala\u0301n a legritka\u0301bb esetben tala\u0301lkozunk a pontos gyo\u0301gyszersze\u00ad de\u0301ssel, hiszen betegeink legto\u0308bbszo\u0308r tu\u0301lszedik, vagy nem szedik az a\u0301ltalunk javasolt gyo\u0301gyszert. A gyo\u0301gyszerabu\u0301zus vagy \u00addependencia jo\u0301l ismert proble\u0301ma, melynek etiolo\u0301gia\u0301ja\u0301val, ko\u0308vetkezme\u0301\u00ad nyeivel sze\u0301lesko\u0308rben foglalkozik az irodalom. Tova\u0301bbi gyakori szitua\u0301cio\u0301, amikor a kezele\u0301s elutasi\u0301ta\u0301sa olyan ko\u0301rke\u0301pekhez ta\u0301rsul, mely esetekben a betegse\u0301gbela\u0301ta\u0301s hia\u0301nya a\u0301ll a ha\u0301tte\u0301rben (pl.: szkizofre\u0301nia). Ugyanakkor pszichia\u0301terke\u0301nt igen gyakran szembesu\u0308lu\u0308nk egy harmadik betegcsoporttal, amikor a pa\u0301ciens elutasi\u0301tja vagy bizalmatlan a javasolt gyo\u0301gyszerrel szemben, e\u0301s arra hivatkozik, hogy \u201efe\u0301l, hogy ra\u0301szokik a gyo\u0301gyszerre\u201d, vagy \u201eatto\u0301l tart, hogy fu\u0308ggo\u030bve\u0301 va\u0301lik a gyo\u0301gyszerekto\u030bl\u201d. Az esetek to\u0308bb\u00ad se\u0301ge\u0301ben ez az e\u0301rze\u0301s vagy elo\u030bi\u0301te\u0301let az addiktofo\u0301bia jelense\u0301gko\u0308re\u0301be tartozik, mely fogalmat ne\u0301ha\u0301ny e\u0301ve i\u0301rta\u0301k le elo\u030bszo\u0308r a szakirodalomban. Ebben az esetben az egyu\u0308ttmu\u030bko\u0308de\u0301s nem a betegse\u0301ghez ko\u0308theto\u030b (az elneveze\u0301sben a \u201efo\u0301bia\u201d szo\u0301 nem egy specifikus ko\u0301rke\u0301pre utal), sokkal inka\u0301bb ta\u0301je\u0301kozatlansa\u0301g, illetve ta\u0301rsadalmi, kultura\u0301lis hata\u0301sok ko\u0308vetkezme\u0301nye. A negati\u0301v attitu\u030bddel jellemezheto\u030b ellene\u0301rze\u0301s le\u0301nyege, hogy irraciona\u0301lis, vagy legala\u0301bbis tu\u0301le\u0301rte\u0301kelt tartalmak e\u0301s\/vagy ele\u0301gtelen informa\u0301cio\u0301 alapja\u0301n hoz do\u0308nte\u0301st a pa\u0301ciens a tudoma\u0301nyosan megalapozott szakmai javaslatot figyelmen ki\u0301vu\u0308l hagyva. Emellett szinte\u0301n jellemzo\u030b, hogy azok a psziche\u0301s zavarok, melyek jelento\u030bs szenvede\u0301st okozva orvoshoz fordula\u0301sra ke\u0301sztette\u0301k a beteget, progredia\u0301lnak az addiktofo\u0301bia oka\u0301n vesztett ido\u030b miatt. A pa\u0301ciensek ilyenkor jellemzo\u030ben ho\u0301napokig, aka\u0301r e\u0301vekig pro\u0301ba\u0301lkoznak a\u0301ltaluk keve\u0301sbe\u0301 addikti\u0301vnak tartott techni\u00ad ka\u0301k alkalmaza\u0301sa\u0301val a gyo\u0301gyno\u0308ve\u0301nyes ke\u0301szi\u0301tme\u0301nyekto\u030bl a die\u0301ta\u0301kon a\u0301t a csontkova\u0301csig, igen komoly anyagi a\u0301ldozatot va\u0301llalva.<\/p>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”Gene-sex interaction in Hypercompetitive Attitude suggests beneficial effect of the DRD4 7-repeat allele in adaptation” url=”\/magazin\/pdf\/vol21issue2\/v21i2p47.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”\/magazin\/pdf\/vol21issue2\/v21i2p47.pdf” link_option_url_new_window=”on”]<\/p>\n Julianna Bircher, Eszter Kotyuk, Marta Fulop, Andrea\u00a0Vereczkei, Zsolt Ronai, Katalin VArga\u00a0and Anna Szekely<\/p>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n 1 Doctoral School of Psychology, ELTE Eo\u0308tvo\u0308s Lora\u0301nd University, Budapest, Hungary Twin studies provide evidence for the heritability of social attitudes, e.g. competitiveness, however, there are no psychogenetic association results linking competitive attitudes to ge- netic polymorphisms. Candidate gene studies report association with competitiveness-related phenotypes, risk taking for example was linked with the 7-repeat allele of the dopamine D4 receptor gene. This polymorphism has been studied extensively with novelty seeking and certain psychiatric disorders, as it plays a crucial role in molecular genetic mechanisms driving behavioral responses to the environment, especially modulating behavior through the reward circuitry. In the present study, we examined association of the DRD4 48-bp VNTR and competitiveness using self-report data from 399 non-related Caucasians. We found an interesting gene-sex interaction: 7-carrier males were more hypercompetitive as compared to non-carriers, while 7-carrier females were less hypercompetitive as compared to non-carriers. This finding remained significant after Bonferroni correction for multiple testing. Interestingly, among females we observed a significant positive correlation between hypercompetitiveness and mood characteristic variables, however, no such relationship could be detected in males. In 7-carrier females the association of hypercompetitiveness and anxiety or depression was more robust as compared to non-carrier females. These results highlight the importance of cultural influences in interpreting gene-sex interaction effects. Our results underlies interaction between genes and the environment; suggesting that the 7-repeat allele plays an important role in adaptivity, enabling sex-specific behavior to social expectations.<\/p>\n (Neuropsychopharmacol Hung 2019; 21(2): 47\u201358)<\/p>\n Keywords: DRD4 polymorphism, 7-repeat allele competitive attitudes, hypercompetitiveness, self-development competitiveness, gene-sex interaction, adaptivity<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”The effect of acute and repeated administration of buspirone, 8-OHDPAT and fluoxetine on haloperidol-induced extrapyramidal symptoms” url=”\/magazin\/pdf\/vol21issue2\/v21i2p59.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”\/magazin\/pdf\/vol21issue2\/v21i2p59.pdf”]<\/p>\n Sara Ami Ahmadi, Mohammadmahdi Sabahi and Rasool Haddadi [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n 1 Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran Objective: The aim of this study was to investigate the effect of buspirone, as a partial agonist of 5-HT1A receptors, 8-hydroxy-2-[di-n-propylamino]-tetralin (8-OH-DPAT) as an agonist of 5-HT1A receptors and fluoxetine as a selective serotonin reuptake inhibitor on haloperidol-induced extrapyramidal symptoms (EPS) in male Wistar rats. Materials and methods: The experi- ments were performed on 66 male Wistar rats weighing 200-240g. The rats were divided into 11 groups (n=6). Extrapyramidal symptoms were induced by haloperidol injection 1mg\/kg intraperitoneally (i.p.). To investigate the effect of serotonergic drugs on haloperidol-induced extrapyramidal symptoms, 8-OHDPAT (1 mg\/kg), buspirone (10 mg\/kg), and fluoxetine (1 mg\/kg) were injected before haloperidol in an acute and 7 consecutive day\u2019s pre-treatment injection(s) mode. Extrapyramidal symptoms such as catalepsy and motor balance were assessed by the bar test and rotarod, respectively. Findings: The results demonstrated that i.p. injection of haloperidol induced significant motor imbalance and catalepsy (p\u22640.001) in rats. Data analysis showed that i.p. injection of buspirone (10 mg\/kg) significantly decreased catalepsy compared with the control group. The attenuation of haloperidol-induced extrapy- ramidal symptoms was observed with 8-OHDPAT treatment. Treatment with fluoxetine did not affect the motor coordination caused by haloperidol. Conclusion: It may be concluded that buspirone and 8-OHDPAT improves extrapyramidal symptoms in a haloperidol-induced Parkinsonism model probably via activation of 5-HT1A receptors. However, further investiga- tions should be carried out to clarify the exact mechanism of interaction between 5-HT1A and DA receptors.<\/p>\n (Neuropsychopharmacol Hung 2019; 21(2): 59\u201368)<\/p>\n Keywords: haloperidol, fluoxetine, buspirone, catalepsy, 8-OHDPAT, motor balance, extrapy- ramidal symptoms<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”Cotard-syndrome associated with Hashimoto encephalopathy: a case report” url=”\/magazin\/pdf\/vol21issue2\/v21i2p85.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”\/magazin\/pdf\/vol21issue2\/v21i2p85.pdf” link_option_url_new_window=”on”]<\/p>\n Luca Hajnal, Judit Laz\u00e1ry<\/em><\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n There is a growing body of data on encephalopathy-related psychiatric syndromes in the literature, however, clinical management of them still remains a great challenge. Although organic background of the rarely identified Cotard-syndrome has been reported in numerous pathological states, Hashimoto-encephalopathy has not been published in association with this clinical phenotype so far. In this paper we present a case of a 44 year old woman, who previously never had a psychiatric disorder and her clinical symptoms corresponded to Cotard II syndrome. She produced psychotic depression with nihilistic doxasmas related to shutting down, clogging and rotting of her organs. These psychiatric symptoms were accompanied by cognitive, motor and vegetative signs, therefore we systematically excluded all organic brain disorders described in the literature. Besides the bizarre mental symptoms we found significantly increased anti-TPO levels in her serum, aspecific pathological signs on\u00a0 cull MR scans and thyreoid disease in the medical history. After differential diagnostic analyses we diagnosed Hashimoto-encephalopathy (HE), which was confirmed by positive clinical response to steroid therapy. Certain forms of HE (also named as steroid-responsive encephalopathy associated with autoimmune thyreoiditis, SREAT) are frequently associated with psychiatric syndromes but Cotard-syndrome has not been described so far in relation with this disease. Keywords:<\/strong> Cotard symptom, Cotard syndrome, Hashimoto-encephalopathy, SREAT, anti-TPO, [\/et_pb_toggle][et_pb_blurb title=”Novel findings concerning the heritability of IQ” url=”\/magazin\/pdf\/vol21issue2\/v21i2p69.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”\/magazin\/pdf\/vol21issue2\/v21i2p69.pdf” link_option_url_new_window=”on”]<\/p>\n Ujma\u00a0 P<\/em>rzemyslaw Pe\u0301ter<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n IQ is a psychological indicator with exceptional psychometric properties and substantial real-life predictive power. Behavior genetic results have long suggested that IQ is strongly heritable, that is, inter-individual IQ differences are mostly due to genetic differences, and that the effects of the environment shared by siblings, such as the family\u2019s place of residence or socioeconomic status, is minimal. Recently these observations were confirmed by quantitative genetic studies of unprecedented sample sizes, SNP heritability studies combining quantitative and molecular genetic approaches, and genome-wide association studies identifying specific genetic variants underlying IQ. Genome-wide association studies enable the creation of polygenic scores which correlate with actual cognitive ability at approximately r=0.3. Keywords:<\/strong> IQ, intelligence, heritability, genetics, GWAS, GCTA, genome-wide association study, [\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/07\/2019-2sz-borito.png” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.25.4″ box_shadow_style=”preset3″][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Volume 21, Issue 2, June 2019 (1941\u20132019) Addiktofo\u0301bia: a gyo\u0301gyszerre szoka\u0301sto\u0301l valo\u0301 fe\u0301lelem Laz\u00e1ry Judit A pszichia\u0301triai betegek ella\u0301ta\u0301sa sora\u0301n tala\u0301n a legritka\u0301bb esetben tala\u0301lkozunk a pontos gyo\u0301gyszersze\u00ad de\u0301ssel, hiszen betegeink legto\u0308bbszo\u0308r tu\u0301lszedik, vagy nem szedik az a\u0301ltalunk javasolt gyo\u0301gyszert. A gyo\u0301gyszerabu\u0301zus vagy \u00addependencia jo\u0301l ismert proble\u0301ma, melynek etiolo\u0301gia\u0301ja\u0301val, ko\u0308vetkezme\u0301\u00ad nyeivel sze\u0301lesko\u0308rben foglalkozik az irodalom. […]<\/p>\n","protected":false},"author":4,"featured_media":48339,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[52],"project_tag":[],"class_list":["post-48516","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-2019-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=48516"}],"version-history":[{"count":23,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48516\/revisions"}],"predecessor-version":[{"id":49524,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48516\/revisions\/49524"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48339"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=48516"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=48516"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=48516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
2 Institute of Psychology, ELTE Eo\u0308tvo\u0308s Lora\u0301nd University, Budapest, Hungary
3 Department of Clinical Psychology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
4 MTA-ELTE Lendu\u0308let Adaptation Research Group, Institute of Psychology, ELTE Eo\u0308tvo\u0308s Lora\u0301nd University, Budapest, Hungary 5 Institute for Cognitive Neuroscience and Psychology, Hungarian Academy of Sciences, Budapest, Hungary
6 Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary<\/p>\n
<\/em><\/p>\n
2 Medicinal Plant and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran 3 Department of Pharmacology, School of Pharmacy, Hamadan University of medical sciences, Hamadan, Iran
* These authors contributed equally to this work<\/p>\n
This case raises attention on the significance of autoimmune diseases in the pathomechanism of psychiatric disorders and further highlights the importance of interdisciplinary diagnostic methods in the psychiatry.<\/p>\n
organic psychiatric disorder<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
The increasing understanding of the genetic basis of IQ, especially the use of polygenic scores validates previous quantitative genetic paradigms and clears the path for several applications in psychology, but it may also be the source of bioethical dilemmas.<\/p>\n
genome-wide complex trait study, polygenic score<\/p>\n<\/div>\n<\/div>\n<\/div>\n