[et_pb_section fb_built=”1″ _builder_version=”3.22″ custom_padding=”28px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.25″ custom_padding=”27px|0px|0|0px|false|false”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ header_font=”||||||||” header_text_color=”#000000″ header_4_font=”|700||on|||||” header_4_text_align=”center” header_4_text_color=”#000000″ header_4_font_size=”19px” header_4_letter_spacing=”1px”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”3.22″ custom_padding=”24px|0px|25px|0px|false|false”][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Editoral in Hungarian” url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/szerklevel_honlapra.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/szerklevel_honlapra.pdf” link_option_url_new_window=”on”]<\/p>\n
A pszichofarmakol\u00f3gia m\u00faltja, jelen \u00e9s j\u00f6v\u0151je<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.21.4″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
P\u00e9ter L\u00e1szl\u00f3<\/span><\/p>\n <\/p>\n<\/div>\n A m\u00falt sz\u00e1zad 50-60-as \u00e9veit\u0151l kezdve a pszichi\u00e1triai betegs\u00e9gek etiol\u00f3gi\u00e1j\u00e1nak egyre jobb megismer\u00e9s\u00e9n keresztu\u0308l az el\u00e9rhet\u0151 pszichofarmakonok sz\u00e1ma ugr\u00e1sszer\u0171en megn\u0151tt. A monoamin hipot\u00e9zis bevezet\u00e9s\u00e9t k\u00f6vet\u0151en a dopamin, szerotonin \u00e9s noradrenalin neurotranszmisszi\u00f3t befoly\u00e1sol\u00f3 szerek szinte az eg\u00e9sz vil\u00e1gon el\u00e9rhet\u0151v\u00e9 v\u00e1ltak. A hagyom\u00e1nyos vagy t\u00edpusos gy\u00f3gyszerekre jellemz\u0151 volt a nagy hat\u00e9konys\u00e1g, viszont mivel sz\u00e1mos egy\u00e9b receptor m\u0171k\u00f6d\u00e9s\u00e9t is \u00e9rintett\u00e9k, ez\u00e9rt a mell\u00e9khat\u00e1sprofiljuk nagyon kedvez\u0151tlen volt. Ennek hat\u00e1s\u00e1ra indult meg a pszichofarmakonok fejleszt\u00e9s\u00e9nek 2. nagyobb hull\u00e1ma az 1980-90-es \u00e9vekben. A szelektiv szerotonin reuptake g\u00e1tl\u00f3k (SSRI-k), a kett\u0151s hat\u00e1s\u00fa antidepressz\u00edvumok vagy az at\u00edpusos antipszichotikumok sokkal kevesebb\u00a0mell\u00e9khat\u00e1ssal rendelkeztek, \u00e9s hat\u00e9konys\u00e1guk sem maradt el a kor\u00e1bbi szerek\u00e9t\u0151l. Az ut\u00f3bbi 10-15 \u00e9vben igaz\u00e1n \u00faj hat\u00e1smechanizmus\u00fa szer nem keru\u0308lt piacra, ink\u00e1bb a kor\u00e1bbi hat\u00f3anyagok m\u00f3dos\u00edtott vagy kombin\u00e1lt v\u00e1ltozatait l\u00e1thatjuk. Napjainkban a generikus gy\u00f3gyszerek t\u00e9rh\u00f3d\u00edt\u00e1sa figyelhet\u0151 meg vil\u00e1gszerte, az origin\u00e1lis k\u00e9sz\u00edtm\u00e9nyek d\u00f6nt\u0151en finansz\u00edroz\u00e1si okok miatt kikopnak az el\u00e9rhet\u0151 gy\u00f3gyszerpalett\u00e1b\u00f3l. A j\u00f6v\u0151 kutat\u00f3inak tal\u00e1n el kellene gondolkozniuk azon, hogy a r\u00e9gebbi gy\u00f3gyszerek hat\u00e9konys\u00e1g\u00e1t hogyan lehetne kombin\u00e1lni az \u00fajabb szerek mell\u00e9khat\u00e1sprofilj\u00e1val. Emellett persze l\u00e1thatunk t\u00f6rekv\u00e9seket olyan m\u00e1s betegs\u00e9gekben haszn\u00e1lt gy\u00f3gyszerek pszichi\u00e1triai adapt\u00e1ci\u00f3j\u00e1ra is, melyek nem a monoamin hipot\u00e9zist veszik alapul, hanem pl. a pszichi\u00e1triai betegs\u00e9geket egyfajta gyullad\u00e1sk\u00e9nt aposztrof\u00e1lj\u00e1k. T\u00f6rt\u00e9ntek m\u00e1r vizsg\u00e1latok gyullad\u00e1scs\u00f6kkent\u0151kkel, anticitokin szerekkel, prosztaglandin inhibitorokkal, immunszupressz\u00edv gy\u00f3gyszerekkel is. B\u00e1r az eredm\u00e9nyek biztat\u00f3ak, de haszn\u00e1latuk egyel\u0151re m\u00e9g nem terjedt el a k\u00f6ztudatban.<\/span><\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”The development of a short version of TEMPS-A in Hungarian non-clinical samples” url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/lang_honlapra.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.5″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/lang_honlapra.pdf” link_option_url_new_window=”on”]<\/p>\n Andras Lang, Barbara Papp, Tamas Inancsi, Peter Dome, Xenia Gonda, \u00a0Zoltan Rihmer, and Zsuzsanna Belteczki<\/span><\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]Background: The Temperament Evaluation of Memphis, Pisa and San Diego Autoquestionnaire Keywords: affective temperaments, TEMPS-A, short version, Hungarian[\/et_pb_toggle][et_pb_blurb title=”Assessing suicide risk using the Brief Suicide Questionnaire \u2013 preliminary results” url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/rihmer_honlapra.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/rihmer_honlapra.pdf”]<\/p>\n Zoltan Rihmer, Peter Dome, Xenia Gonda, Annamaria Rihmer and Zsuzsanna Belteczki<\/span><\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]The authors tested the clinical applicability of a self-developed, 6-item, clinician-rated Keywords: suicide, suicide attempt, suicide risk factors, hierarchical classification, sensitivity, Ildik\u00f3 Sipos<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]The recognition of the antibody-mediated encephalitis as a separate entity among the immune Keywords: anti-NMDAR antibody, autoimmune enkefalitisz, psychosis, immunotherapy[\/et_pb_toggle][et_pb_blurb title=”The practical considerations of antidepressant use during pregnancy and breastfeeding” url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/dome_honlapra.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/dome_honlapra.pdf”]<\/p>\n P\u00e9ter D\u00f6me and G\u00e1bor Faludi <\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]Main indications of antidepressants (ADs) as major depressive disorder (MDD) and different Keywords: antidepressant, affective disorders, pregnancy, breastfeeding[\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/borito_honlapra_kicsi.jpg” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ box_shadow_style=”preset3″][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" \u2022 A pszichofarmakol\u00f3gia m\u00faltja, jelen \u00e9s j\u00f6v\u0151je – P\u00e9ter L\u00e1szl\u00f3
\n
\n(TEMPS-A) is a widely used measure of affective temperaments. Affective temperaments refer
\nto people\u2019s prevailing moods and are important precursors of affective disorders. With the
\ntwo studies presented in this paper, we aimed to develop a short version of the Hungarian
\nTEMPS-A. Methods: A total number of 1857 university students participated in two studies.
\nThe original 110-item version and the newly developed short version of TEMPS-A, the anger,
\ndepression, and anxiety scales of the PROMIS Emotional Distress item bank, the Altman SelfRating Mania Scale, the Satisfaction With Life Scale, and the Well-Being Index were administered to participants. Results: Out of the original 110 items, 40 items of TEMPS-A loaded on
\nfive factors that represented the five affective temperaments. Factors of the short version
\nshowed moderate to strong correlations with their original counterparts. All factors had
\ngood to excellent internal reliability. Factors of the newly developed short version of TEMPSA showed meaningful correlations with measures of emotional distress, mania, and indices
\nof psychological well-being. Conclusions: The short version of the Hungarian TEMPS-A is a
\npromising instrument both in clinical fields and for academic research. The newly developed
\nshort version proved to be a valid and reliable measure of affective temperaments.
\n(Neuropsychopharmacol Hung 2018; 20(1): 4\u201313)<\/p>\n
\nquestionnaire evaluating suicide risk in suicidal and non-suicidal psychiatric inpatients and
\nhealthy controls. Results have shown that the questionnaires able to detect marked suicide risk
\nin psychiatric inpatients with a high sensitivity and specificity which indicates its usefulness
\nand good applicability in clinical practice.<\/p>\n
\nspecificity[\/et_pb_toggle][et_pb_blurb title=”N-methyl-D-aspartate receptor antibody encephalitis: the Janus-faced disorder” url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/sipos_honlapra.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xx-evfolyam-1-szam\/sipos_honlapra.pdf”]<\/p>\n
\ndisorders of the central nervous system was one of the greatest breakthroughs of the last two
\ndecades in neurology. Unlike viral or tumor-related encephalitis, the antibody-mediated form
\nhas a good response to immunotherapy, which gives a special clinical importance to the discovery. Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is one of the first fully
\ncharacterized antibody-mediated encephalitises. This article attempts to summarize the clinical
\nfeatures of this complex neuropsychiatric disorder with the aim to help its early recognition
\nand to report the clinical course and the outcome of our six seropositive anti-NMDAR cases.
\nThe disease appears typically in young females and often combined with ovarian teratoma.
\nHowever, the antibody production could develop without any malignancy. The course of the
\nillness is usually monophasic, but 10% of the cases are relapsing. The anti-NMDAR encephalitis
\nis the result of disturbed glutamatergic neurotransmission due to the internalization of the
\nreceptor-antibody complexes. The disease usually develops after a common viral infection,
\nbut recent data proved that anti-NMDAR encephalitis could also develop after herpes simplex
\nvirus-1 encephalitis. The Janus-faced clinical course of the disease is the obstacle of the early
\nrecognition. Psychiatric symptoms \u2013 like delusion, hallucination and agitation \u2013 dominate in
\nthe first, cortical phase of the illness, which are indistinguishable from the signs of primary
\npsychosis. The true nature of the disease only reveals later, with the appearance of the basal
\nganglia territory and brainstem sings, such as perioral hyperkinesia and bradycardia. Further
\ndelays the diagnosis that the leading symptoms of the second phase could be interpreted as
\nthe side effects of the initial treatment. According to expert psychiatrists, the unusual dynamic
\nof the psychotic symptoms and the lack of response to the neuroleptic drugs could lead toward
\nthe idea of the anti-NMDAR encephalitis. The final diagnosis depends on the detection of the
\nanti-NMDAR antibody from the cerebrospinal fluid or the serum, respectively. Haloperidol is
\nthe most potent drug to treat the psychotic symptoms of the cortical phase; however due
\nto its antidopaminergic side effect atypical neuroleptics are recommended by the experts.
\nThe immunological treatment is the administration of intravenous corticosteroid combined
\nwith plasma exchange or with intravenous IgG infusion. The immunotherapy in most of the
\ncases is successful, but the recovery is long and it requires strong cooperation between the
\npsychiatrists, neurologists and intensive care therapists.<\/p>\n
\nkinds of anxiety disorders are quite prevalent during pregnancy and the postpartum period.
\nDue to the possible hazards of in utero and breast milk exposition of ADs, both psychiatrists
\nand mothers frequently have concerns about the use of ADs during the periods of pregnancy
\nand breastfeeding. However, we should also bear in mind that affective disorders left untreated
\nduring these periods are also associated with health risks for the mother and the baby as well.
\nAccordingly, the treatment of affective disorders during these periods is essential. For mild
\ncases of affective disorders the recommended treatment modality is typically psychotherapy
\nwhile for the severe cases pharmacotherapy (including AD treatment) is recommended.
\nUnfortunately, due to the lack of well-designed prospective studies, only sparse information
\nis available on the efficacy and safety of AD treatment in pregnant and breastfeeding women.
\nIn this review we try to provide some practical advice in terms of the use of ADs during the
\nperiods in question.<\/p>\n
\n\u2022 The development of a short version of TEMPS-A in Hungarian non-clinical samples –
\nAndras Lang, Barbara Papp, Tamas Inancsi, Peter Dome, Xenia Gonda, Zoltan Rihmer, and Zsuzsanna Belteczki<\/p>\n","protected":false},"author":4,"featured_media":48279,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[57],"project_tag":[],"class_list":["post-48521","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-neuropsychopharmacologia-hungarica-2-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=48521"}],"version-history":[{"count":8,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48521\/revisions"}],"predecessor-version":[{"id":49507,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48521\/revisions\/49507"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48279"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=48521"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=48521"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=48521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}