{"id":48525,"date":"2017-03-20T13:20:05","date_gmt":"2017-03-20T13:20:05","guid":{"rendered":"https:\/\/mppt.hu\/project\/2017-marcius-xix-evfolyam-1-szam\/"},"modified":"2020-10-19T20:24:54","modified_gmt":"2020-10-19T20:24:54","slug":"2017-marcius-xix-evfolyam-1-szam","status":"publish","type":"project","link":"https:\/\/mppt.hu\/en\/project\/2017-marcius-xix-evfolyam-1-szam\/","title":{"rendered":"Volume 19, Issue 1, March 2017"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”3.22.3″ custom_padding=”28px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.25″ custom_padding=”27px|0px|0|0px|false|false”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ header_font=”||||||||” header_text_color=”#000000″ header_4_font=”|700||on|||||” header_4_text_align=”center” header_4_text_color=”#000000″ header_4_font_size=”19px” header_4_letter_spacing=”1px” custom_padding=”1px|||||”]<\/p>\n

Volume 19, Issue 1, March 2017<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”3.22.3″ custom_padding=”24px|0px|25px|0px|false|false”][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Editoral in Hungarian ” url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/szerk_lev_jav_2.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/szerk_lev_jav_2.pdf” link_option_url_new_window=”on”]<\/p>\n

Az affekt\u00edv betegs\u00e9gek t\u00e1rsadalmi jelent\u0151s\u00e9ge, ku\u0308l\u00f6n\u00f6s tekintettel az auto- \u00e9s heteroagressz\u00edv megnyilv\u00e1nul\u00e1sokra<\/strong><\/p>\n

Rihmer Zolt\u00e1n, \u00e9s Blazsek P\u00e9ter \u00a0<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n

Szerkeszt\u0151s\u00e9gi lev\u00e9l<\/h3>\n
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Az affekt\u00edv betegs\u00e9gek t\u00e1rsadalmi jelent\u0151s\u00e9ge, ku\u0308l\u00f6n\u00f6s tekintettel az auto- \u00e9s heteroagressz\u00edv megnyilv\u00e1nul\u00e1sokra<\/h4>\n
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Rihmer Zolt\u00e1n1,2<\/sup>\u00a0\u00e9s Blazsek P\u00e9ter2<\/sup><\/p>\n

 <\/p>\n

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 <\/p>\n

1<\/sup>\u00a0Semmelweis Egyetem, Pszichi\u00e1triai \u00e9s Pszichoter\u00e1pi\u00e1s Klinika, Budapest
2<\/sup>\u00a0Ny\u00edr\u0151 Gyula K\u00f3rh\u00e1z – Orsz\u00e1gos Pszichi\u00e1triai \u00e9s Addiktol\u00f3giai Int\u00e9zet, Pszichi\u00e1triai Gondoz\u00f3, Budapest<\/em><\/p>\n<\/div>\n

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A depresszi\u00f3 orvosi \u00e9rtelemben vett betegs\u00e9g, \u00e9s sokkal sz\u0171kebb kateg\u00f3ri\u00e1t jelent, mint a t\u00e1rsadalmi illetve egy\u00e9ni probl\u00e9m\u00e1k \u00e1ltal motiv\u00e1lt szomor\u00fas\u00e1g vagy rossz k\u00f6z\u00e9rzet. Az unipol\u00e1ris major depresszi\u00f3 az egyik leggyakoribb pszichi\u00e1triai betegs\u00e9g. Hat eur\u00f3pai orsz\u00e1gra kiterjed\u0151 nagy nemzetk\u00f6zi felm\u00e9r\u00e9s szerint a major depresszi\u00f3k egy \u00e9ves prevalenci\u00e1ja \u00e1tlagosan 5 sz\u00e1zal\u00e9k, \u00e9s az Eur\u00f3pai Uni\u00f3ban az \u00e9vente major depresszi\u00f3ban szenved\u0151 betegek sz\u00e1ma kb. 18,4 milli\u00f3ra tehet\u0151 (Wittchen \u00e9s Jacobi, 2005). Hazai felm\u00e9r\u00e9sek szerint a major depresszi\u00f3 1 \u00e9ves \u00e9s 1 h\u00f3napos prevalenci\u00e1ja a feln\u0151tt lakoss\u00e1g k\u00f6r\u00e9ben 7,1% \u00e9s 2,6%, m\u00edg a bipol\u00e1ris betegs\u00e9g\u00e9 2,7% \u00e9s 1,3%, teh\u00e1t n\u00e1lunk ezen betegs\u00e9gek el\u0151fordul\u00e1si gyakoris\u00e1ga az eur\u00f3pai \u00e1tlagn\u00e1l magasabb. Haz\u00e1nkban a major depresszi\u00f3s betegek csak mintegy 40-45% \u00e1ll gy\u00f3gyszeres kezel\u00e9s alatt. Az unipol\u00e1ris major depresszi\u00f3 2010-ben a vil\u00e1gon a harmadik leggyakoribb oka volt a teljes eg\u00e9szs\u00e9gben meg\u00e9lhet\u0151 \u00e9let\u00e9vek elveszt\u00e9s\u00e9nek (Disability Adjusted Life Years, DALY), \u00e9s a 2020-ra sz\u00f3l\u00f3 el\u0151rejelz\u00e9sek szerint az iszk\u00e9mi\u00e1s sz\u00edvbetegs\u00e9g m\u00f6g\u00f6tt a m\u00e1sodik helyet foglalja majd el. Ugyanakkor el\u0151rejelz\u00e9sek alapj\u00e1n 2030-ra az unipol\u00e1ris depresszi\u00f3 \u00e9s a k\u00f6vetkezm\u00e9nyes \u00f6ngyilkoss\u00e1g lesz a DALY leggyakoribb oka (M\u00f6ller \u00e9s mtsai, 2012).<\/p>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Association between the 5-HTTLPR polymorphism of the serotonin transporter gene and suicide: a case-control pilot study” url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/bokor_eredeti_honlapra_jav.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/bokor_eredeti_honlapra_jav.pdf” link_option_url_new_window=”on”]<\/p>\n

A szerotonin transzporter g\u00e9n 5-HTTLPR polimorfizmusa \u00e9s az \u00f6ngyilkoss\u00e1g \u00f6sszefu\u0308gg\u00e9se: eset-kontroll elrendez\u00e9s\u0171 pilot vizsg\u00e1lat<\/strong><\/p>\n

Bokor J\u00e1nos, Gonda X\u00e9nia, D\u00f6me P\u00e9ter, Faludi G\u00e1bor, Dinya Elek, L\u00e1szik Andr\u00e1s<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n

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Objectives: Besides psychological and social effects, biological, biochemical and genetic
factors also play a role in the background of suicide. The aim is developing a complex model
incorporating all the above factors so that suicide could be predicted and prevented in those
at risk. Based on several studies 5-HTTLPR s allele frequency is increased in case of violent
completed suicides. The aim of the present study was to validate this association in a sample
of completed suicides. Methods: During autopsy sample DNA samples were obtained for
5-HTTLPR genotyping from 200 subjects deceased due to suicide and 200 controls deceased
due to other causes. Chi square tests and logistic regressions were performed according
to additive, dominant and recessive models to analyse the possible association between
5-HTTLPR genotype distribution and suicide. Results: Ratio of violent and non-violent suicides
was 81% and 19% respectively. No significant difference was found in the distribution of
5-HTTLPR genotypes between the suicide and controls samples. No difference was found
between violent and nonviolent suicides with respect to genotype distribution. A significant
association was found between sl genotype and suicide at a younger age. Conclusions: Our
pilot study did not support the supposed association between 5-HTTLPR and completed suicides or with violent completed suicides. However we found a significant association between
sl genotype and suicide in young suicidals.<\/p>\n

Keywords: serotonin transporter gene, 5-HTTLPR, violent suicide, nonviolent suicide, completed suicide<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”The impact of currently recommended antihypertensive therapy on depression and other psychometric parameters: preliminary communication” url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/korosi_eredeti.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/korosi_eredeti.pdf”]<\/p>\n

Beata Korosi*, Andrea Laszlo*, Adam Tabak, *, Dora Batta, Lilla Lenart, Andrea Fekete, Daniel Eorsi, Orsolya Cseprekal, Andras Tisler, Zsofia Nemcsik-Bencze, Xenia Gonda, Zoltan Rihmer, Janos Nemcsik, \u00a0<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n

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Aims: <\/strong>Current evidence on the psychological effects of antihypertensive medications is controversial. The aim of this study was to evaluate the effect of current antihypertensive medication on different psychometric parameters and on serum brain-derived neurotrophic factor (BDNF) level.\u00a0Methods:<\/strong>\u00a0Psychometric, haemodynamic, arterial stiffness and laboratory parameters were evaluated before and 3 months after the initiation of antihypertensive medication in untreated hypertensive patients (HT, n=31), and once in healthy controls (CONT, n=22). Subjects completed the following psychometric tests: Beck Depression Inventory (BDI), Hamilton Anxiety Scale (HAM-A), Symptom Checklist 90 Revised (SCL-90), Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire, Big Five Inventory, Pain Vigilance and Awareness Questionnaire and Berkeley Expressivity Questionnaire. Amlodipine and\/or perindopril compounds were preferred medications. Serum BDNF was measured with ELISA.\u00a0Results:<\/strong>\u00a0Brachial systolic blood pressure, as well as pulse wave velocity were significantly improved in the HT group over the 3-month follow-up (153.3\u00b115.9 mmHg vs. 129.5\u00b110.0 mmHg and 8.2\u00b11.4 m\/s vs 7.5\u00b11.6 m\/s, respectively). Similarly, we found improvements in BDI (0.73 points) and in several Scl-90 subscales. Serum BDNF was not different between CONT and HT and did not change for therapy.\u00a0Conclusions:<\/strong>\u00a0Our results indicate that initiation of currently recommended antihypertensive medications in newly diagnosed patients may have a significant impact on psychological well-being of patients and could influence quality of life as well.<\/p>\n

\n

(Neuropsychopharmacol Hung 2017; 19(1): 11\u201322)
<\/em>
<\/em>Keywords:<\/strong>\u00a0antihypertensive medication, depression, arterial stiffness, psychiatric symptoms, affective temperaments, brain-derived neurotrophic factor<\/p>\n<\/div>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Similarities and differences between bipolar disorder and hypertension: may be mania is the hypertension of the mood?” url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/rihmer_osszefoglalo.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/rihmer_osszefoglalo.pdf”]<\/p>\n

Zolt\u00e1n Rihmer, X\u00e9nia, Gonda, P\u00e9ter D\u00f6me, L\u00eddia Harmati, J\u00e1nos Nemcsik<\/em><\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n

A possibly shared pathophysiological background between bipolar disorders and essential
hypertension is suggested by the several similarities and overlaps between their genetic
background, underlying biological disturbances (including partially shared neuroanatomical
and neurochemical correlates), concomitant personality and temperamental characteristics,
precipitating factors, comorbidity and treatment response. In this paper we outline and extend
our previously published hypothesis discussing the similar origins of these two biphasic\/
bidirectional phenomena.<\/p>\n

Keywords: bipolar disorder, mania, hypertension, hypothesis<\/p>\n

[\/et_pb_toggle][et_pb_blurb title=”Why are migraineurs more depressed? A review of the factors contributing to the comorbidity of migraine and depression” url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/baksa_osszefoglalo.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xix-evfolyam-1-szam\/baksa_osszefoglalo.pdf”]<\/p>\n

Daniel Baksa, Xenia Gonda, Gabriella Juhasz<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” hover_enabled=”0″ border_width_all=”0px” border_width_bottom=”1px” sticky_enabled=”0″]<\/p>\n

The comorbidity of migraine and depression is well-known. Patients with both conditions show stronger headache-related symptoms, a more severe clinical course and higher risk for migraine chronification. Therefore, it\u2019s important to identify factors underlying comorbid migraine and depression. The growing body of literature suggests complex, biopsychosocial mechanisms in the background, including shared genetic risk factors and abnormal brain mechanisms, and also different environmental (stress) and psychological variables (for example: rumination, neuroticism). In this short review we summarize the most important findings regarding the interacting factors in the pathomechanism of the co-existence of migraine and depression. Finally, we conclude some therapeutical considerations regarding treatment of patients with the migraine-depression phenotype.<\/div>\n
\n

(Neuropsychopharmacol Hung 2017; 19(1): 37\u201344)
<\/em>
Keywords:<\/strong>\u00a0migraine, depression, comorbidity, genetics, brain mechanisms, stress, rumination, therapy, review<\/p>\n<\/div>\n

[\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/05\/b1_2017_marcius_web_kicsi.jpg” url_new_window=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.6.5″ box_shadow_style=”preset3″][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Volume 19, Issue 1, March 2017Az affekt\u00edv betegs\u00e9gek t\u00e1rsadalmi jelent\u0151s\u00e9ge, ku\u0308l\u00f6n\u00f6s tekintettel az auto- \u00e9s heteroagressz\u00edv megnyilv\u00e1nul\u00e1sokra Rihmer Zolt\u00e1n, \u00e9s Blazsek P\u00e9ter \u00a0Szerkeszt\u0151s\u00e9gi lev\u00e9l Az affekt\u00edv betegs\u00e9gek t\u00e1rsadalmi jelent\u0151s\u00e9ge, ku\u0308l\u00f6n\u00f6s tekintettel az auto- \u00e9s heteroagressz\u00edv megnyilv\u00e1nul\u00e1sokra Rihmer Zolt\u00e1n1,2\u00a0\u00e9s Blazsek P\u00e9ter2     1\u00a0Semmelweis Egyetem, Pszichi\u00e1triai \u00e9s Pszichoter\u00e1pi\u00e1s Klinika, Budapest 2\u00a0Ny\u00edr\u0151 Gyula K\u00f3rh\u00e1z – Orsz\u00e1gos Pszichi\u00e1triai […]<\/p>\n","protected":false},"author":4,"featured_media":48295,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[58],"project_tag":[],"class_list":["post-48525","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-neuropsychopharmacologia-hungarica-3-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48525","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=48525"}],"version-history":[{"count":13,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48525\/revisions"}],"predecessor-version":[{"id":49528,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48525\/revisions\/49528"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48295"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=48525"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=48525"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=48525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}