[et_pb_section fb_built=”1″ _builder_version=”3.22.7″ custom_padding=”||5px|||”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.6″ hover_enabled=”0″ custom_padding=”1px|||||” sticky_enabled=”0″]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”3.22.3″ custom_padding=”24px|0px|25px|0px|false|false”][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Editoral in Hungarian ” url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/szerklevel_tenyi.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/szerklevel_tenyi.pdf” link_option_url_new_window=”on” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n
Tam\u00e1s\u00a0 T\u00e9nyi and Gy\u00f6rgyi Cs\u00e1bi<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
T\u00e9nyi Tam\u00e1s \u00e9s Cs\u00e1bi Gy\u00f6rgyi<\/p>\n<\/div>\n
Ahogy j\u00f3l ismert, a szkizofr\u00e9nia klinikailag heterog\u00e9n \u00e9s komplex k\u00f3reredet\u0171 betegs\u00e9g, mely kialakul\u00e1s\u00e1nak h\u00e1tter\u00e9ben a genetikai faktorok jelent\u0151s szerepet j\u00e1tszanak (a heritabilit\u00e1s 0,41-0,87% k\u00f6z\u00f6tt mozog). A betegs\u00e9g kutat\u00e1s\u00e1nak egyik legjelent\u0151sebb neh\u00e9zs\u00e9ge, hogy jelent\u0151s ismeretlen ter\u00fclet h\u00faz\u00f3dik a k\u00f3rk\u00e9p kialakul\u00e1s\u00e1\u00e9rt felel\u0151s g\u00e9nek \u00e9s a gyakorlatban l\u00e1tott klinikai t\u00fcnetek k\u00f6z\u00f6tt. Ennek oka, hogy a szkizofr\u00e9nia patogenezise igen \u00f6sszetett \u00e9s bonyolult, amely gyenge predikt\u00edv kapcsolatot eredm\u00e9nyez a klinikai diagn\u00f3zis \u00e9s a h\u00e1tt\u00e9rben megh\u00faz\u00f3d\u00f3 genetikai okok k\u00f6z\u00f6tt. Az endofenot\u00edpusok (intermedier fenot\u00edpusok) kutat\u00e1sa jelent\u0151s szerepet j\u00e1tszhat a fenti neh\u00e9zs\u00e9gek megold\u00e1s\u00e1ban \u00e9s tiszt\u00e1z\u00e1s\u00e1ban. Az endofenot\u00edpusok kvantitat\u00edv neurobiol\u00f3giai saj\u00e1ts\u00e1gok, amelyek azonban a mindennapi klinikai gyakorlatot m\u0171vel\u0151 \u201epuszta szem\u201d sz\u00e1m\u00e1ra csak ritk\u00e1n vagy nem l\u00e1that\u00f3k, amelyek kutat\u00e1sa azonban k\u00f6zelebb vihet a k\u00f3rk\u00e9p etiol\u00f3gi\u00e1j\u00e1nak felt\u00e1r\u00e1s\u00e1hoz (Braff, 2015). Gottesman \u00e9s Gould (2003) defin\u00edci\u00f3ja szerint az endofenot\u00edpus (1) egy adott betegs\u00e9ghez kapcsol\u00f3dik, (2) \u00f6r\u00f6kl\u0151dik, (3) \u00e1llapot-f\u00fcggetlen, a betegs\u00e9g b\u00e1rmely szakasz\u00e1ban \u2013 \u00edgy a premorbid id\u0151szakban \u00e9s remisszi\u00f3ban is \u2013 \u00e9szlelhet\u0151, (4) t\u00fcnetmentes hozz\u00e1tartoz\u00f3kban magasabb gyakoris\u00e1g\u00fa, mint az \u00e1tlag popul\u00e1ci\u00f3ban \u00e9s (5) csal\u00e1di halmoz\u00f3d\u00e1st mutat.<\/p>\n<\/div>\n
[\/et_pb_toggle][et_pb_blurb title=”The potential use of ayahuasca in psychiatry” url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/frecska_nph_2016_junius.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/frecska_nph_2016_junius.pdf” link_option_url_new_window=”on”]<\/p>\n
Ede Frecska, Petra Bokor, G\u00e1bor\u00a0 Andr\u00e1ssy and Attila Kov\u00e1cs<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
Ayahuasca is a decoctum made of admixture plants containing dimethyltryptamine and
harmine. For millennia it has been used as a central element of spiritual, religious, initiation,
and other \u2013 foremost healing \u2013 rituals, originally by the indigenous groups of the Amazon
basin and later by the mestizo populations of the region. During the last two decades the
brew has raised increased scientific and lay interest about its healing potentials within the
framework of Western therapeutic settings. The typical ayahuasca effects consist of strong
somatic reactions, vivid visions, relived personal memories, cathartic emotions, and insightful,
introspective experiences when the emerging mental contents take different context and get
deeper perspectives. The ayahuasca-experience can be exhausting necessitating the presence
of an experienced leader for helping participants to pass difficult phases and for maximizing
therapeutic benefits. No health damaging adverse effect has been confirmed thus far as result
of its well-structured, institutionalized use. The scientific investigation of ayahuasca is hindered
by legal issues, methodical problems, and sociocultural preconceptions. The present review
outlines the therapeutic potentials of ayahuasca use in psychiatry with its psychobiological
and spiritual background.<\/p>\n
Keywords: addictions, ayahuasca, depression, dimethyltryptamine, post-traumatic stress
disorder<\/p>\n
[\/et_pb_toggle][et_pb_blurb title=”Behavioural aspects of a modified crosstalk between basal ganglia and limbic system in Parkinson\u2019s disease” url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/gyorfi_nph_2016_junius.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/gyorfi_nph_2016_junius.pdf”]<\/p>\n
Orsolya Gyorfi, Helga Nagy, Magdolna Bokor and Szabolcs Keri<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
<\/p>\n<\/div>\n
Dysfunctions in dopaminergic neurotransmission lead to motor symptoms and cognitive impairments associated with behavioural disturbances. Parkinson\u2019s disease is a neurodegenerative disorder which is primarily characterized by an abnormal basal ganglia activity. Recently, increased attention has been directed towards the hippocampus in the development of non-motor symptoms. Given the temporal progression of the disease, dopaminergic depletion firstly affects the dorsal striatum leaving the ventral striatum relatively intact. However, it is possible that the structure and function of the hippocampus shows alterations even in early stages of Parkinson\u2019s disease. Subtle cognitive impairments occur in the earliest stages, and therefore Parkinson\u2019s disease could provide a unique model to investigate the effect of replacement therapies on a neural network with different baseline dopaminergic levels. Strong evidence suggests that dopaminergic medications improve the motor symptoms, but these medications might have disadvantageous effects on cognitive functions. In this review, we examine the role of dopaminergic changes across several cognitive and behavioural impairments observed in Parkinson\u2019s disease, with a special reference to hippocampal\u00a0
dysfunctions.<\/p>\n
(Neuropsychopharmacol Hung 2016; 18(2): 087\u2013092)<\/em><\/p>\n Keywords:\u00a0<\/strong>Parkinson\u2019s disease, hippocampus, dopaminergic neurotransmission, cognitive function<\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”Major obstacles in the development of child and adolescent psychiatry in Hungary” url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/kalmar_nph_2016_junius.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/kalmar_nph_2016_junius.pdf”]<\/p>\n S\u00e1ndor Kalm\u00e1r<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n The author ascertains that healthy personality development faces increasingly serious obstacles Keywords: child and adolescent psychiatry, key persons, mental illiteracy, biological-psychological-mental-cultural-social-spiritual model, role of central nervous system alterations<\/p>\n [\/et_pb_toggle][et_pb_blurb title=”Catatonia in disulfiram intoxication \u2013 a case report and a brief overview of the literature” url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/takacs_nph_2016_junius.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/takacs_nph_2016_junius.pdf”]<\/p>\n Rozalia Takacs, Flora Milan, Gabor S. Ungvari, Gabor Faludi and Gabor Gazdag<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n <\/p>\n<\/div>\n Catatonic syndromes could accompany a variety of psychiatric and medical conditions. The most common conditions underlying catatonia are affective disorders followed by schizophrenia, but several medical conditions including intoxications affecting the central nervous system can also present with catatonic signs and symptoms. Therapeutic doses of disulfiram could induce catatonia with or without accompanying psychosis or mood disorder. A case of disulfiram intoxication manifesting with catatonia is reported here together with a brief overview of the literature. A patient was admitted to the toxicology ward after a suicide attempt with approximately 20 g of disulfiram. On transfer to the psychiatric ward, she was sitting still, in a semi-stuporous state and displayed motiveless resistance to instructions or attempts to move (active negativism). She was unresponsive to most of the questions (mutism), occasionally verbigerated 1-2 words and stared for more than 20 seconds between shifting attention. After developing a comatosus state her treatment continued at the toxicology ward, where a contrast-enhanced computer tomography scan revealed bilateral emollition of 1.5 cm diameter in both nucleus lentiformis at the level of the third ventricle. Following treatment her condition improved and she benefited of rehabilitation facility and a second psychiatric treatment. She was discharged free of neurological and psychiatric symptoms. In conclusion, we underscore the importance of accurate diagnosis of the underlying psychiatric or medical condition when encountering a fast emerging catatonic syndrome and focus first on treating the causative condition while simultaneously attempting symptomatic treatment of catatonia.<\/p>\n (Neuropsychopharmacol Hung 2016; 18(2): 110\u2013114)<\/em><\/p>\n Keywords:<\/strong>\u00a0disulfiram, intoxication, neuropsychiatric complications, catatonia<\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”Marchiafava\u2013Bignami disease (Case-report)” url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/pinter_nph_2016_junius.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-2-szam\/pinter_nph_2016_junius.pdf”]<\/p>\n Gy\u00f6rgy Pint\u00e9r, Krisztina\u00a0 Borb\u00e9ly and L\u00e1szl\u00f3 P\u00e9ter<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n Marchiafava\u2013Bignami disease (MBD) is caused by damage of the corpus callosum. There Keywords: Marchiafava\u2013Bignami disease, alcoholism, dementia, corpus callosum<\/p>\n [\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/05\/b1_2016_jun_kicsi.jpg” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ box_shadow_style=”preset3″][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" VOLUME 18, ISSUE 2, JUNE 2016 Tam\u00e1s\u00a0 T\u00e9nyi and Gy\u00f6rgyi Cs\u00e1biT\u00fcnetmentes hozz\u00e1tartoz\u00f3k vizsg\u00e1lata szkizofr\u00e9ni\u00e1ban \u2013 endofenotipikus markerek azonos\u00edt\u00e1sa fel\u00e9 T\u00e9nyi Tam\u00e1s \u00e9s Cs\u00e1bi Gy\u00f6rgyi Ahogy j\u00f3l ismert, a szkizofr\u00e9nia klinikailag heterog\u00e9n \u00e9s komplex k\u00f3reredet\u0171 betegs\u00e9g, mely kialakul\u00e1s\u00e1nak h\u00e1tter\u00e9ben a genetikai faktorok jelent\u0151s szerepet j\u00e1tszanak (a heritabilit\u00e1s 0,41-0,87% k\u00f6z\u00f6tt mozog). A betegs\u00e9g kutat\u00e1s\u00e1nak egyik legjelent\u0151sebb neh\u00e9zs\u00e9ge, […]<\/p>\n","protected":false},"author":4,"featured_media":48300,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[59],"project_tag":[],"class_list":["post-48528","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-neuropsychopharmacologia-hungarica-4-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48528","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=48528"}],"version-history":[{"count":15,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48528\/revisions"}],"predecessor-version":[{"id":49592,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48528\/revisions\/49592"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48300"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=48528"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=48528"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=48528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
and consequently the number of children in need of mental healthcare is on the rise. Child
and adolescent psychiatry has drawn increasing appreciation, however, it is only formal and
deficient in Hungary today and cannot assure optimal mental care according to the principles
of evidence-based medicine. The author emphasizes that 75% of the first manifestation of the
psychiatric disorders occurs during adolescence and young adulthood. In spite of legal regulation, several deficiencies hinder the development of children into healthy adults. The author
analyses the most important obstacles in the development of child and adolescent Psychiatry.
The author emphasizes the role of keypersons, describes the situation of and problems faced
by Hungarian child psychiatric care. The author lists in detail the most important contradictions, deficiencies and obstacles and outlines suggestions for resolving the present crisis.
The author emphasizes (1) the responsibility of institutions, and people dealing with society
and children, and the disinterest of competent authorities. (2) The somatic, mental, cultural
and spiritual ignorance\/illiteracy among parents, teachers, healthcare workers, and the general
population partly related to crises among the pedagogues. (3) The lack of holistic approach
to treatment of children suffering from mental disorder. (4) The importance and the lack
of knowledge concerning central nervous system function in child psychiatry. (5) Application
of evidence-based medicine in child and adolescent psychiatry based on understanding the
relationship between central nervous system alterations and mental functions. (6) Respecting
keypersons\u2019 competence limits. (7) Immediate development of inpatient and outpatient child
and adolescent psychiatry in the whole country. (8) Reform of child psychiatry board exam.
(9) Development of currently missing textbooks and handbooks and promoting benefits
of internet use. (10) The almost complete lack of the permanent and systematic mental health
prevention in education and healthcare, especially in primary health care. (11) The ignorance
of possible and achievable opportunities. Overcoming the obstacles of child and adolescent
psychiatry can only be achieved by a coordinated action of dedicated child psychiatrists, child
psychologists, informed parents, well-trained pediatricians, district nurses, excellent teachers
and other committed keypersons.<\/p>\n
\n
are acute, subacute and chronic forms, it occurs most frequently among alcoholic patients.
A variety of neurological symptoms, epileptic seizures, and coma may be associated with the
disease, but the chronic form may start with acute confusion and dementia, interhemispherial disconnection syndrome or with slow progressive changes in behavior. In 2001, only 250
cases were reported, of which 200 died, 30 cases contributed to severe dementia or bed rest,
and favorable outcome occured in only 20 cases. The MBD diagnosis of our patient was based
on the anamnesis and cranial MRI and the treatment consisted of administration of B vitamin
complex, folic acid, memantine, piracetam and haloperidol. Reviewing the international literature currently recommended therapeutic options are thiamin and folic acid. According to
some authors the immediate administration of thiamine affects the outcome of the disease,
and there are case reports of beneficial effects of amantadine and steroids.<\/p>\n