{"id":48529,"date":"2016-03-20T15:09:24","date_gmt":"2016-03-20T15:09:24","guid":{"rendered":"https:\/\/mppt.hu\/project\/2016-marcius-xviii-evfolyam-1-szam\/"},"modified":"2020-10-19T19:21:11","modified_gmt":"2020-10-19T19:21:11","slug":"2016-marcius-xviii-evfolyam-1-szam","status":"publish","type":"project","link":"https:\/\/mppt.hu\/en\/project\/2016-marcius-xviii-evfolyam-1-szam\/","title":{"rendered":"Volume 18, Issue 1, March 2016"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22.7&#8243; custom_padding=&#8221;||2px|||&#8221;][et_pb_row _builder_version=&#8221;3.25&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;3.27.4&#8243;]<\/p>\n<h4 class=\"title\" style=\"text-align: center;\">VOLUME 18, ISSUE 1, MARCH2016<\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; specialty=&#8221;on&#8221; _builder_version=&#8221;3.22.3&#8243; custom_padding=&#8221;24px|0px|25px|0px|false|false&#8221;][et_pb_column type=&#8221;3_4&#8243; specialty_columns=&#8221;3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_row_inner _builder_version=&#8221;3.25&#8243;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;Editoral in Hungarian &#8221; url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/szerkesztosegi_level_marcius_2016.pdf&#8221; url_new_window=&#8221;on&#8221; image=&#8221;https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png&#8221; icon_placement=&#8221;left&#8221; image_max_width=&#8221;105%&#8221; content_max_width=&#8221;1100px&#8221; _builder_version=&#8221;3.22.7&#8243; header_font=&#8221;||||||||&#8221; header_font_size=&#8221;17px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;||on||||||&#8221; body_line_height=&#8221;1.3em&#8221; link_option_url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/szerkesztosegi_level_marcius_2016.pdf&#8221; link_option_url_new_window=&#8221;on&#8221;]<\/p>\n<p>Frecska Ede and Andr\u00e1s Per\u00e9nyi<\/p>\n<p>[\/et_pb_blurb][et_pb_toggle title=&#8221;Abstract &#8221; closed_toggle_text_color=&#8221;#000000&#8243; closed_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; icon_color=&#8221;#0c71c3&#8243; _builder_version=&#8221;3.22.7&#8243; title_font=&#8221;|600|||||||&#8221; title_letter_spacing=&#8221;1px&#8221; text_orientation=&#8221;justified&#8221; custom_padding=&#8221;0px||10px&#8221; border_width_all=&#8221;0px&#8221; border_width_bottom=&#8221;1px&#8221;]<\/p>\n<h4 class=\"art\">\u201eHit and run\u201d: A pszichofarmakol\u00f3gia r\u00e9gi paradigm\u00e1ja \u00faj k\u00f6nt\u00f6sben<\/h4>\n<div class=\"autors\">\n<p>Frecska Ede<sup>1<\/sup>\u00a0\u00e9s Per\u00e9nyi Andr\u00e1s<sup>2<\/sup><\/p>\n<hr id=\"system-readmore\" \/>\n<p>&nbsp;<\/p>\n<p><em><sup>1<\/sup>\u00a0Pszichi\u00e1triai Klinika, Debreceni Egyetem Klinikai K\u00f6zpont, Debrecen<\/em><\/p>\n<p><em><sup>2<\/sup>\u00a0Delmont Hospital, 298 Warrigal Road, Glen Iris, Victoria, 3146, Australia<\/em><\/p>\n<\/div>\n<hr class=\"system-readmore\" \/>\n<div class=\"artbody\">\n<p>K\u00f6zel 5 \u00e9ve \u00edrtam [F. E.] ezeken a has\u00e1bokon a pszichofarmakol\u00f3gia korszakv\u00e1lt\u00e1s\u00e1r\u00f3l. Akkor egy \u00f6tven \u00e9ven \u00e1t tart\u00f3, lend\u00fcletes progresszi\u00f3ra hivatkoztam, \u00e9s agg\u00e1lyomnak adtam kifejez\u00e9st egy lassul\u00e1sra utal\u00f3 tendenci\u00e1ra (nevezetesen az ipar \u00e9rdekl\u0151d\u00e9s\u00e9nek cs\u00f6kken\u00e9s\u00e9re) utalva. Visszatekintve t\u00e1rszerz\u0151mmel [P. A.] ma m\u00e1sk\u00e9pp hangs\u00falyozn\u00e1nk a dolgokat. Az \u00f6tven \u00e9ven \u00e1t tart\u00f3 \u201elend\u00fcletes progresszi\u00f3t\u201d most \u00fagy m\u00f3dos\u00edtan\u00e1nk, hogy b\u00e1r a pszichofarmakonok f\u00e9l \u00e9vsz\u00e1zad alatt sokat fejl\u0151dtek a mell\u00e9khat\u00e1sok tekintet\u00e9ben, \u00e1m a hat\u00e9konys\u00e1gban mutatkoz\u00f3 javul\u00e1st illet\u0151en fenntart\u00e1saink vannak. Az \u2013 els\u0151sorban az antidepressz\u00edvumok ter\u00fclet\u00e9n tapasztalt \u2013 l\u00e1tv\u00e1nyos fejl\u0151d\u00e9s legink\u00e1bb a kiterjedt fel\u00edr\u00e1sban nyilv\u00e1nul meg: tekintetbe v\u00e9ve a sz\u00e9lesebb indik\u00e1ci\u00f3s ter\u00fcletet \u00e9s a v\u00e9ny\u00edr\u00f3k sz\u00e1m\u00e1nak nagys\u00e1g\u00e1t (nem csak pszichi\u00e1ter, m\u00e1s szakorvos, s\u0151t helyenk\u00e9nt pszichol\u00f3gus \u00e9s szakk\u00e9pzett n\u0151v\u00e9r, clinical nurse practitioner is rendelheti). Mindez a biztons\u00e1goss\u00e1g javul\u00e1s\u00e1nak k\u00f6sz\u00f6nhet\u0151. A k\u00f6nnyebb fel\u00edrhat\u00f3s\u00e1g k\u00e9ts\u00e9gk\u00edv\u00fcl sok szerepet j\u00e1tszott a depresszi\u00f3 \u00e1tfog\u00f3bb \u00e9s teljesebb kezel\u00e9s\u00e9ben (itt hangs\u00falyozn\u00e1nk a jobb ter\u00e1pi\u00e1s egy\u00fcttm\u0171k\u00f6d\u00e9st), \u00e9s \u00edgy az \u00f6ngyilkoss\u00e1g visszaszor\u00edt\u00e1s\u00e1ban. Azonban ez a \u201esiker\u201d k\u00e9t\u00e9l\u0171 \u00e9s t\u00e1mad\u00e1sokra ad alapot: a pszichofarmakonok elterjedt fel\u00edr\u00e1sa m\u00e1r-m\u00e1r vissza\u00fct szakm\u00e1nkra, v\u00e1daskod\u00e1sokra vezet (miszerint mindez az ipari lobbi hat\u00e1sa, r\u00e1ad\u00e1sul a pszichoter\u00e1pia elsorvaszt\u00e1s\u00e1nak ir\u00e1ny\u00e1ba hat stb.).<\/p>\n<\/div>\n<p>[\/et_pb_toggle][et_pb_blurb title=&#8221;Alzheimer\u2019s disease and diabetes \u2013 the common pathogenesis&#8221; url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/halmos_marcius_2016.pdf&#8221; url_new_window=&#8221;on&#8221; image=&#8221;https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png&#8221; icon_placement=&#8221;left&#8221; image_max_width=&#8221;105%&#8221; content_max_width=&#8221;1100px&#8221; _builder_version=&#8221;3.22.7&#8243; header_font=&#8221;||||||||&#8221; header_font_size=&#8221;17px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;||on||||||&#8221; body_line_height=&#8221;1.3em&#8221; link_option_url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/halmos_marcius_2016.pdf&#8221; link_option_url_new_window=&#8221;on&#8221;]<\/p>\n<p>Tam\u00e1s Halmos and Ilona Suba<\/p>\n<p>[\/et_pb_blurb][et_pb_toggle title=&#8221;Abstract &#8221; closed_toggle_text_color=&#8221;#000000&#8243; closed_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; icon_color=&#8221;#0c71c3&#8243; _builder_version=&#8221;3.22.7&#8243; title_font=&#8221;|600|||||||&#8221; title_letter_spacing=&#8221;1px&#8221; text_orientation=&#8221;justified&#8221; custom_padding=&#8221;0px||10px&#8221; border_width_all=&#8221;0px&#8221; border_width_bottom=&#8221;1px&#8221;]<\/p>\n<p>Epidemiological studies presented evidence that Alzheimer\u2019s disease and type 2 diabetes<br \/>share common features in their pathophysiology and clinical patterns. Insulin resistance is<br \/>a characteristic feature of both diseases. According to the pathomechanism, inflammatory,<br \/>metabolic, and an atypical form based on the deficiency of zinc ions can be distinguished.<br \/>Glucose metabolic disorders, related to Alzheimer\u2019s disease, are type 2 diabetes, and prediabetes\/metabolic syndrome. Based on the common pathophysiological patterns of these two<br \/>diseases, Alzheimer\u2019s disease is customary called type 3 diabetes. In the research on dementias,<br \/>insulin resistance stands in the highlight for its documented harmful effects on cognitive<br \/>function and causes dementia. Insulin-like growth factor also influences cognitive functions.<br \/>Reduced input of this hormone into the brain may also cause dementia, however literary data<br \/>are controversial. In Alzheimer\u2019s disease, deposition of amyloid \u00df in the brain, hyperphosphorylation of tau proteins and dysruption of neurofibrilles are characteristic. Amyloid \u00df is<br \/>co-secreted in the \u00df-cells of the pancreas with insulin. Amyloid \u00df and hyperphosphorylated<br \/>tau protein were detected in the Langerhans islets by autopsy. Amyloid deposits, found<br \/>in the pancreas and brain presented similarities. As a consequence of hyperglycemia, glycation endproducts cause the development of amyloid plaques, dysruption of neurofibrilles,<br \/>and activated microglia, all are typical to Alzheimer\u2019s disease. Continuous hyperglycemia<br \/>leads to oxidative stress, which used to play significant role in the development of both<br \/>diseases. Low-grade inflammation is also a significant pathophysiological factor in both disorders. The sources of inflammation are proinflammatorical adipocytokines, dysbacteriosis,<br \/>metabolic endotoxaemia, caused by lipopolysaccharides, and high fat diet which also lead<br \/>to insulin resistance. Based on recent data, microbial amyloid, the main product of bacteria,<br \/>is also contributing to the pathophysiology of the human central nervous system. Alzheimer\u2019s<br \/>disease is a heterogeneous disorder, and as yet there is no effective therapy. Encouraging<br \/>results have emerged by using intranasal insulin spray. Insulin sensitizers like metformin,<br \/>thiazolidines have also resulted in improvements in cognitive functions, mainly in animal<br \/>experiments. Glucagon-like peptide-1, beyond its insulin-stimulating effect, also has central<br \/>pleiotropic influences. Research results with the application of these molecules seem to be<br \/>enouraging. More recently, glucagon-like peptide-1, and glucose-dependent insulinotropic<br \/>peptide were administered together, with promising early results. The real breakthrough has<br \/>not yet arrived. For the time being we have to endeavour to the prevention of both chronic<br \/>diseases via a more healthy life-style.<\/p>\n<p>Keywords: Alzheimer\u2019s disease, diabetes, insulin resistance, inflammation, amyloid \u00df, therapy<\/p>\n<p>[\/et_pb_toggle][et_pb_blurb title=&#8221;Autotelic activities aimed at the alteration of the human body from socially accepted to pathological forms: about non-suicidal self-injury&#8221; url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/kalmar_marcius_2016.pdf&#8221; url_new_window=&#8221;on&#8221; image=&#8221;https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png&#8221; icon_placement=&#8221;left&#8221; image_max_width=&#8221;105%&#8221; content_max_width=&#8221;1100px&#8221; _builder_version=&#8221;4.6.6&#8243; header_font=&#8221;||||||||&#8221; header_font_size=&#8221;17px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;||on||||||&#8221; body_line_height=&#8221;1.3em&#8221; link_option_url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/kalmar_marcius_2016.pdf&#8221;]<\/p>\n<p>Kalm\u00e1r S\u00e1ndor<\/p>\n<p>[\/et_pb_blurb][et_pb_toggle title=&#8221;Abstract &#8221; closed_toggle_text_color=&#8221;#000000&#8243; closed_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; icon_color=&#8221;#0c71c3&#8243; _builder_version=&#8221;3.22.7&#8243; title_font=&#8221;|600|||||||&#8221; title_letter_spacing=&#8221;1px&#8221; text_orientation=&#8221;justified&#8221; custom_padding=&#8221;0px||10px&#8221; border_width_all=&#8221;0px&#8221; border_width_bottom=&#8221;1px&#8221;]<\/p>\n<p class=\"art\">The author lays down that non-suicidal self-injury (NSSI) constitutes an increasingly more<br \/>common and serious public health problem, especially during the age of adolescence. In spite<br \/>of the fact that the phenomenon has been known since the beginning of human mankind even<br \/>in animals, we have not been able to either give a clear explanation or prevent its spreading yet.<br \/>The author reviews the conceptual disturbances, behavioural phenotypes, cultural-historical<br \/>and mythological antecedents related to self-injury, just as the controversial concepts, reasons<br \/>of unclearness of the concepts, and clinical classification of self-injuries, and he outlines a new<br \/>categorisation\/ classification of the explanation of autotelic activities aimed at the alteration<br \/>of the human body. He reviews the relationship between self-injuries and other psychological signs and symptoms and psychiatric illnesses, the explanations of developing self-injurious behaviour and further research directions. Besides the different models of self-injury<br \/>he presents a holistic model. Besides the therapeutic guidelines of self-injurious behaviour,<br \/>he calls the attention to the importance of genetic and nervous system researches, psychological and spiritual research, the importance of mental education and prevention, and he<br \/>also lists some more essential questions future researchers have to find the answers for if we<br \/>would like all children to be allowed to enter the adults&#8217; world in a healthy and sound state.<\/p>\n<p class=\"art\">Keywords: non-suicidal self-injury (NSS), behavioural phenotypes, self-injurious behaviours<br \/>(SIB), self-injury, deliberate self-harm (DSH), disturbances of the development of personality,<br \/>clinical classification, treatment and prevention of self-injurious behaviours<\/p>\n<p>[\/et_pb_toggle][et_pb_blurb title=&#8221;Possible effects of climate changes (particularly heat waves) on body functions with a special emphasis on subjects taking psychopharmacons: a narrative review&#8221; url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/radics_marcius_2016.pdf&#8221; url_new_window=&#8221;on&#8221; image=&#8221;https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png&#8221; icon_placement=&#8221;left&#8221; image_max_width=&#8221;105%&#8221; content_max_width=&#8221;1100px&#8221; _builder_version=&#8221;4.6.6&#8243; header_font=&#8221;||||||||&#8221; header_font_size=&#8221;17px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;||on||||||&#8221; body_line_height=&#8221;1.3em&#8221; link_option_url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/radics_marcius_2016.pdf&#8221;]<\/p>\n<p>Judit Radics<\/p>\n<p>[\/et_pb_blurb][et_pb_toggle title=&#8221;Abstract &#8221; closed_toggle_text_color=&#8221;#000000&#8243; closed_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; icon_color=&#8221;#0c71c3&#8243; _builder_version=&#8221;3.22.7&#8243; title_font=&#8221;|600|||||||&#8221; title_letter_spacing=&#8221;1px&#8221; text_orientation=&#8221;justified&#8221; custom_padding=&#8221;0px||10px&#8221; border_width_all=&#8221;0px&#8221; border_width_bottom=&#8221;1px&#8221;]<\/p>\n<p class=\"art\">Climate change and global warming have become increasingly discussed in the last few years<br \/>\u2013 but mainly as an economical-social problem. Due to the preceding years&#8217; hot summers,<br \/>as a clinical psychiatrist I considered it important to examine the effect of heat on body functions especially among those who are taking psychiatric drugs. The problem has a clinical<br \/>significance, since heat is an extreme environmental factor with unexpected consequences.<br \/>Due to heat various adverse reactions are expected especially in subjects on combined pharmacotherapy regimes. The present article points out the clinical importance of heat and also<br \/>its potential adverse (and sometimes life-threatening) consequences.<\/p>\n<p class=\"art\">Keywords: climate change, heat wave, clinics, pharmacotherapy, psychiatry<\/p>\n<p>[\/et_pb_toggle][et_pb_blurb title=&#8221;Iowa Gambling Task: illustration of a behavioral measurement&#8221; url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/eisinger_marcius_2016.pdf&#8221; url_new_window=&#8221;on&#8221; image=&#8221;https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png&#8221; icon_placement=&#8221;left&#8221; image_max_width=&#8221;105%&#8221; content_max_width=&#8221;1100px&#8221; _builder_version=&#8221;4.6.6&#8243; header_font=&#8221;||||||||&#8221; header_font_size=&#8221;17px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;||on||||||&#8221; body_line_height=&#8221;1.3em&#8221; link_option_url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/eisinger_marcius_2016.pdf&#8221;]<\/p>\n<p>Andrea Eisinger, Anna Magi, M\u00e1t\u00e9 Gyurkovics, Edina Szab\u00f3, Zsolt\u00a0 Demetrovics and Gy\u00f6ngyi K\u00f6k\u00f6nyei<\/p>\n<p>[\/et_pb_blurb][et_pb_toggle title=&#8221;Abstract &#8221; closed_toggle_text_color=&#8221;#000000&#8243; closed_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; icon_color=&#8221;#0c71c3&#8243; _builder_version=&#8221;3.22.7&#8243; title_font=&#8221;|600|||||||&#8221; title_letter_spacing=&#8221;1px&#8221; text_orientation=&#8221;justified&#8221; custom_padding=&#8221;0px||10px&#8221; border_width_all=&#8221;0px&#8221; border_width_bottom=&#8221;1px&#8221;]<\/p>\n<p class=\"art\">The Iowa Gambling Task is a behavioral measurement which was developed to examine<br \/>decision-making based on the Somatic Marker Hypothesis. Participants have to make series<br \/>of choices altogether 100 times from four decks of cards. The decks have different characteristics with regards to gains and losses. After the initial analyses \u2013 with a focus on patients<br \/>with damage to the ventromedial prefrontal cortex \u2013 the tool soon became one of the most<br \/>frequently used technique of measuring hot executive functions. It is also used to measure<br \/>impulsivity. Structures involved in decision-making constitute the neural basis of the Task. IGT<br \/>is applied in several different disorders (in connection with decision-making and impulsivity<br \/>as well). In recent years different versions have been developed, and these modifications may<br \/>have different effects on IGT performance, and may also influence what the Task measures<br \/>exactly. With growing empirical evidence several questions have arisen in connection with the<br \/>composition of the decks (gain-loss magnitude vs. frequency, prominent deck B phenomenon)<br \/>which suggest to use other indexes as well besides the net scores.<\/p>\n<p class=\"art\">Keywords: Iowa Gambling Task, decision-making, impulsivity, behavioral measurement<\/p>\n<p>[\/et_pb_toggle][et_pb_blurb title=&#8221;Changes in quality of life and work function during phase prophylactic lamotrigine treatment in bipolar patients: 6 month, prospective, observational study&#8221; url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/gonda_marcius_2016.pdf&#8221; image=&#8221;https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png&#8221; icon_placement=&#8221;left&#8221; image_max_width=&#8221;105%&#8221; content_max_width=&#8221;1100px&#8221; _builder_version=&#8221;3.22.7&#8243; header_font=&#8221;||||||||&#8221; header_font_size=&#8221;17px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;||on||||||&#8221; body_line_height=&#8221;1.3em&#8221; link_option_url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/gonda_marcius_2016.pdf&#8221;]<\/p>\n<p>X\u00e9nia Gonda,J\u00e1nos K\u00e1lm\u00e1n, P\u00e9ter D\u00f6me, and Zolt\u00e1n Rihmer<\/p>\n<p>[\/et_pb_blurb][et_pb_toggle title=&#8221;Abstract &#8221; closed_toggle_text_color=&#8221;#000000&#8243; closed_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; icon_color=&#8221;#0c71c3&#8243; _builder_version=&#8221;3.22.7&#8243; title_font=&#8221;|600|||||||&#8221; title_letter_spacing=&#8221;1px&#8221; text_orientation=&#8221;justified&#8221; custom_padding=&#8221;0px||10px&#8221; border_width_all=&#8221;0px&#8221; border_width_bottom=&#8221;1px&#8221;]<\/p>\n<p>Bipolar disorder is a lifelong illness requiring lifelong pharmacotherapy. Therefore besides<br \/>symptomatic remission, achievement of full work-related functioning and restoration<br \/>of quality of life is a priority during successful treatment. The present prospective, observational,<br \/>non-intervention study focused on investigating the effect of lamotrigine therapy on the<br \/>quality of life and work-related function of bipolar patients in outpatient care. Methods: 969<br \/>bipolar or schizoaffective outpatients participated in the study who previously did not receive<br \/>lamotrigine therapy. Our present phase-prophylactic study was a prospective, observational,<br \/>non-intervention study with a six-month follow-up. Evaluations took place at baseline and at<br \/>months 1, 2, 3 and 6. Patients were followed with a Clinical Global Impression-Severity (CGI-S)<br \/>and Clinical Global Impression-Improvement (CGI-I). Changes in work-related function was<br \/>evaluated using Social Adjustment Scale (SAS), while quality of life was assessed with the<br \/>Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) scale. Results: SAS scoreds<br \/>showed a consistent decrease in the overall sample and in all CGI-S initial groups reflecting<br \/>the improvement of work-related function during the six months of the follow-up. Q-LES-Q<br \/>values in the whole sample and in all initial CGI-S groups showed a steady increase indicating<br \/>a continuous increase in quality of life during the study. Conclusion: Our results indicate that<br \/>during long-term prophylactic lamotrigine therapy the work function and quality of life of<br \/>bipolar patients shows a significant improvement, therefore lamotrigine provides a possibility<br \/>for full functional remission and restoration of quality of life.<\/p>\n<p>Keywords: bipolar disorder, lamotrigine, work function, quality of life<\/p>\n<p>[\/et_pb_toggle][et_pb_blurb title=&#8221;K\u00f6nyvismertet\u00e9s&#8221; url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/konyvismertetes_marcius_2016.pdf&#8221; url_new_window=&#8221;on&#8221; image=&#8221;https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png&#8221; icon_placement=&#8221;left&#8221; image_max_width=&#8221;105%&#8221; content_max_width=&#8221;1100px&#8221; _builder_version=&#8221;4.6.6&#8243; header_font=&#8221;||||||||&#8221; header_font_size=&#8221;17px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;||on||||||&#8221; body_line_height=&#8221;1.3em&#8221; link_option_url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/konyvismertetes_marcius_2016.pdf&#8221;]<\/p>\n<p>Kalm\u00e1r S\u00e1ndor<\/p>\n<p>[\/et_pb_blurb][et_pb_toggle title=&#8221;Abstract &#8221; closed_toggle_text_color=&#8221;#000000&#8243; closed_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; icon_color=&#8221;#0c71c3&#8243; _builder_version=&#8221;3.22.7&#8243; title_font=&#8221;|600|||||||&#8221; title_letter_spacing=&#8221;1px&#8221; text_orientation=&#8221;justified&#8221; custom_padding=&#8221;0px||10px&#8221; border_width_all=&#8221;0px&#8221; border_width_bottom=&#8221;1px&#8221;]<\/p>\n<h4 class=\"art\">K\u00f6nyvismertet\u00e9s<\/h4>\n<div class=\"autors\">\n<p>Kalm\u00e1r S\u00e1ndor<\/p>\n<\/div>\n<hr class=\"system-readmore\" \/>\n<div class=\"artbody\">\n<p><strong>Hippokampusz mint a neuropszichi\u00e1triai betegs\u00e9gek k\u00f6z\u00f6s nevez\u0151je<\/strong><br \/>Szerkesztette: Hal\u00e1sz P\u00e9ter<br \/>Melinda Kiad\u00f3 \u00e9s Rekl\u00e1m\u00fcgyn\u00f6ks\u00e9g, 2005<\/p>\n<\/div>\n<h4 class=\"art\">\u00a0<\/h4>\n<p>[\/et_pb_toggle][et_pb_blurb title=&#8221;Foly\u00f3irat-refer\u00e1tumok&#8221; url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/folyoiratreferatumok_marcius_2016.pdf&#8221; url_new_window=&#8221;on&#8221; image=&#8221;https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png&#8221; icon_placement=&#8221;left&#8221; image_max_width=&#8221;105%&#8221; content_max_width=&#8221;1100px&#8221; _builder_version=&#8221;4.6.6&#8243; header_font=&#8221;||||||||&#8221; header_font_size=&#8221;17px&#8221; header_line_height=&#8221;1.3em&#8221; body_font=&#8221;||on||||||&#8221; body_line_height=&#8221;1.3em&#8221; link_option_url=&#8221;https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/folyoiratreferatumok_marcius_2016.pdf&#8221;]<\/p>\n<p>Urb\u00e1n N\u00f3ra, M\u00f3ra Bal\u00e1zs<\/p>\n<p>[\/et_pb_blurb][et_pb_toggle title=&#8221;Abstract &#8221; closed_toggle_text_color=&#8221;#000000&#8243; closed_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; icon_color=&#8221;#0c71c3&#8243; _builder_version=&#8221;3.22.7&#8243; title_font=&#8221;|600|||||||&#8221; title_letter_spacing=&#8221;1px&#8221; text_orientation=&#8221;justified&#8221; custom_padding=&#8221;0px||10px&#8221; border_width_all=&#8221;0px&#8221; border_width_bottom=&#8221;1px&#8221;]<\/p>\n<h4 class=\"art\">Foly\u00f3irat-refer\u00e1tumok<\/h4>\n<div class=\"autors\">\n<p>Urb\u00e1n N\u00f3ra, M\u00f3ra Bal\u00e1zs<\/p>\n<\/div>\n<hr class=\"system-readmore\" \/>\n<div class=\"artbody\">\n<p><strong>S\u00falyos depresszi\u00f3s betegek kognit\u00edv ter\u00e1pi\u00e1s kezel\u00e9se gy\u00f3gyszerrel kombin\u00e1lva hat\u00e9konyabb, mint az \u00f6n\u00e1ll\u00f3 antidepressz\u00edvum-kezel\u00e9s<\/strong><br \/>Cognitive Therapy Plus Medication Management Is Better Than Antidepressants Alone for Patients With Severe Depression; Sharon C. Sung; Evidence Based Menthal Health, 2015; 18(3): 95.<\/p>\n<p>\u2022<\/p>\n<p><strong>Metilfenid\u00e1t ter\u00e1pia figyelemhi\u00e1nyos\/hiperaktivit\u00e1s zavarral diagnosztiz\u00e1lt gyermekek \u00e9s serd\u00fcl\u0151k k\u00f6r\u00e9ben: randomiz\u00e1lt klinikai vizsg\u00e1latok Cochrane szisztematikus \u00e1ttekint\u00e9se<\/strong><br \/>Methylphenidate for attention-deficit\/hyperactivity disorder in children and adolescents: Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. Ole Jakob Storeb\u00f8; Helle B Krogh; Erica Ramstad; Carlos R Moreira-Maia; Mathilde Holmskov; Maria Skoog; Trine Danvad Nilausen; Frederik L Magnusson; Morris Zwi; Donna Gillies; Susanne Rosendal; Camilla Groth; Kirsten Buch Rasmussen; Dorothy Gauci; Richard Kirubakaran; Bente Forsb\u00f8l; Erik Simonsen; Christian Gluud; BMJ 2015;351:h5203.<\/p>\n<\/div>\n<p>[\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/mppt.hu\/wp-content\/uploads\/2019\/05\/b1_2016_marcius.jpg&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;3.23&#8243; box_shadow_style=&#8221;preset3&#8243;][\/et_pb_image][et_pb_text _builder_version=&#8221;3.27.4&#8243; text_font=&#8221;|700|||on|||#0c71c3|&#8221; text_text_color=&#8221;#0c71c3&#8243; text_font_size=&#8221;13px&#8221; text_letter_spacing=&#8221;1px&#8221;]<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/mppt.hu\/magazin\/pdf\/xviii-evfolyam-1-szam\/impresszum_marcius_2016.pdf\">IMPRESSZUM<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>VOLUME 18, ISSUE 1, MARCH2016Frecska Ede and Andr\u00e1s Per\u00e9nyi\u201eHit and run\u201d: A pszichofarmakol\u00f3gia r\u00e9gi paradigm\u00e1ja \u00faj k\u00f6nt\u00f6sben Frecska Ede1\u00a0\u00e9s Per\u00e9nyi Andr\u00e1s2 &nbsp; 1\u00a0Pszichi\u00e1triai Klinika, Debreceni Egyetem Klinikai K\u00f6zpont, Debrecen 2\u00a0Delmont Hospital, 298 Warrigal Road, Glen Iris, Victoria, 3146, Australia K\u00f6zel 5 \u00e9ve \u00edrtam [F. E.] ezeken a has\u00e1bokon a pszichofarmakol\u00f3gia korszakv\u00e1lt\u00e1s\u00e1r\u00f3l. Akkor egy \u00f6tven \u00e9ven [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":48299,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[59],"project_tag":[],"class_list":["post-48529","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-neuropsychopharmacologia-hungarica-4-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=48529"}],"version-history":[{"count":16,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48529\/revisions"}],"predecessor-version":[{"id":49489,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/48529\/revisions\/49489"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48299"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=48529"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=48529"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=48529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}