[et_pb_section fb_built=”1″ _builder_version=”3.22.7″ custom_padding=”||5px|||”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”3.22.3″ custom_padding=”24px|0px|25px|0px|false|false”][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”In memoriam Dr. Szil\u00e1rd J\u00e1nos Andr\u00e1s” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/in_memoriam_szilard_janos.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/in_memoriam_szilard_janos.pdf” link_option_url_new_window=”on”]<\/p>\n
J\u00e1nos K\u00e1lm\u00e1n<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
K\u00e1lm\u00e1n J\u00e1nos<\/p>\n<\/div>\n
2015. okt\u00f3ber 16-\u00e1n elhunyt Dr. Szil\u00e1rd J\u00e1nos Andr\u00e1s, az orvostudom\u00e1nyok kandid\u00e1tusa, emeritus professzor, a Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Egyetem rektora, az Ideg- \u00e9s Elmegy\u00f3gy\u00e1szati Klinika kor\u00e1bbi tansz\u00e9kvezet\u0151 egyetemi tan\u00e1ra, a Magyar Pszichi\u00e1triai T\u00e1rsas\u00e1g alap\u00edt\u00f3 tagja, a pszichi\u00e1triai szakma \u00f6n\u00e1ll\u00f3sod\u00e1s\u00e1nak, a szoci\u00e1lpszichi\u00e1triai \u00e9s neuropszichi\u00e1triai szeml\u00e9letm\u00f3d jeles hazai k\u00e9pvisel\u0151je.<\/p>\n<\/div>\n
[\/et_pb_toggle][et_pb_blurb title=”Editoral in Hungarian ” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/editorial_bereczki.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/editorial_bereczki.pdf” link_option_url_new_window=”on”]<\/p>\n
D\u00e1niel Bereczki<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
Bereczki D\u00e1niel<\/p>\n<\/div>\n
Magyarorsz\u00e1gon \u00e9vente t\u00f6bb mint 100 ezer fekv\u0151 \u00e9s t\u00f6bb mint 1,3 milli\u00f3 ambul\u00e1ns esetet l\u00e1tnak el a neurol\u00f3giai oszt\u00e1lyok \u00e9s szakrendel\u00e9sek (Bereczki \u00e9s Ajtay, 2009). A neurol\u00f3giai k\u00f3r\u00e1llapotok egy r\u00e9sze (akut stroke, epilepszi\u00e1s rohamok, encefalitisz stb.) s\u00fcrg\u0151s k\u00f3rh\u00e1zi felv\u00e9telt \u00e9s ell\u00e1t\u00e1st ig\u00e9nyel, de a legt\u00f6bb neurol\u00f3giai betegs\u00e9g eset\u00e9ben tart\u00f3s, s\u0151t eg\u00e9sz \u00e9letre sz\u00f3l\u00f3 gondoz\u00e1s sz\u00fcks\u00e9ges. A gondoz\u00e1s r\u00e9szben neurol\u00f3giai szakrendel\u00e9seken t\u00f6rt\u00e9nik, de a szakvizsg\u00e1latok k\u00f6z\u00f6tti id\u0151ben fontos a h\u00e1ziorvos szerepe is.<\/p>\n<\/div>\n
[\/et_pb_toggle][et_pb_blurb title=”Current migraine pharmacotherapy” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/csepany_2015_dec.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/csepany_2015_dec.pdf” link_option_url_new_window=”on”]<\/p>\n
\u00c9va Cs\u00e9p\u00e1ny, M\u00e1t\u00e9 Magyar, Tam\u00e1s Gy\u00fcre, Gy\u00f6rgy\u00a0 Bozsik and Csaba Ertsey<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
The exact pathomechanism of migraine is still unknown, currently there are no biomarkers for
migraine diagnosis, and current animal models reflect only one aspect of migraine, therefore
future migraine studies are necessary. The current treatment of migraine (both acute and
preventive) is suboptimal. There are no specific preventive drugs for migraine, and current
preventatives may become inefficient during long-term use. Triptans are useful abortive
drugs, but not effective in some of the patients; severe cardio-or cerebrovascular side effects
may occur. Triptans and ergot alkaloids (and also non-specific abortive agents) can cause
medication overuse headache. A number of newly synthesized experimental drugs seem to
be effective and promising for migraine therapy, but at present our experience with these is
limited, therefore further studies are essential.<\/p>\n
Keywords: migraine, therapy, triptans, abortive drugs, preventative drugs, ergot alkaloids,
aspirin, paracetamol, non-steroidal anti-inflammatory drugs, antiemetics, newly synthesized
drugs<\/p>\n
[\/et_pb_toggle][et_pb_blurb title=”Tricyclic antidepressant therapy in headache” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/magyar_2015_dec.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/magyar_2015_dec.pdf” link_option_url_new_window=”on”]<\/p>\n
M\u00e1t\u00e9 Magyar, \u00c9va Cs\u00e9p\u00e1ny, Tam\u00e1s Gy\u00fcre, Gy\u00f6rgy Bozsik, D\u00e1niel\u00a0 Bereczki and Csaba Ertsey<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
The two most important representatives of the primary headaches are migraine and tensiontype headache. More than 10% of the population suffer from migraine and even a greater
part, approximately 30-40% from tension-type headache. These two headache types have
a great effect both on the individual and on the society. There are two types of therapeutic
approaches to headaches: the abortive and the prophylactic therapy. Prophylactic treatment
is used for frequent and\/or difficult-to-treat headache attacks. Although both migraine and
tension-type headache are often associated with depression, for their treatment \u2013 in contrast
to the widespread medical opinion \u2013 not all antidepressants were found to be effective.
Amitriptyline, which is a tricyclic antidepressant, is used as a prophylactic therapy for headache
since 1968. Its efficacy has been demonstrated in several double-blind, placebo-controlled
studies. Although the newer types of antidepressant, such as selective serotonin reuptake
inhibitors and selective serotonin-norepinephrine reuptake inhibitor, have a more favorable
side-effect profile than tricyclic antidepressants, their headache prophylactic effect has not
been proven yet.<\/p>\n
Keywords: migraine, tension-type headache, prophylactic treatment, antidepressant, tricyclic
antidepressant<\/p>\n
[\/et_pb_toggle][et_pb_blurb title=”The role of new oral anticoagulants in cerebrovascular diseases” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/orosz_2015_dec.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/orosz_2015_dec.pdf” link_option_url_new_window=”on”]<\/p>\n
P\u00e9ter Orosz<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
Cardioembolisation is responsible for 20 percent of ischaemic stroke cases, which most commonly derives from non-valvular atrial fibrillation. Although warfarin is highly effective in
primary and secondary stroke prevention, its use is limited by the high risk of haemorrhagic
complications and a narrow therapeutic range that needs regular monitoring of INR. These
limitations explained the strong need for developing new oral anticoagulants. The so-called
\u2019new oral anticoagulants\u2019 are trying to find new targets for modifying the coagulation cascade. Apixaban, edoxaban and rivaroxaban are direct factor Xa inhibitors, while dabigatran
works as a direct thrombin inhibitor. Recent phase-III clinical trials proved their effectiveness
in stroke prevention and risk reducing of haemorrhagic events as well, so they can already
be found as recommended drugs in new guidelines of European and American societies of
cardiology and stroke. The use of new oral anticoagulants instead of warfarin in patients with
atrial fibrillation or as a secondary prevention after cardioembolic stroke has to be considered.<\/p>\n
Keywords: stroke, atrial fibrillation, new oral anticoagulants<\/p>\n
[\/et_pb_toggle][et_pb_blurb title=”Application of levodopa\/carbidopa intestinal gel in advanced Parkinson’s disease” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/toth_2015_dec.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/toth_2015_dec.pdf” link_option_url_new_window=”on”]<\/p>\n
Adri\u00e1n T\u00f3th, Helga Nagy, Judit Wacha, D\u00e1niel\u00a0 Bereczki and Annam\u00e1ria Tak\u00e1ts<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
Parkinson\u2019s disease is the second most common neurodegenerative disorder around the
world. Levodopa has remained the \u201dgold standard\u201d of the therapy even several decades
after its introduction. Chronic levodopa treatment is associated with the development of
motor complications in most patients. Advanced Parkinson\u2019s disease is characterized by
these complications: motor and non-motor fluctuation and disturbing dyskinesia. Continuous dopaminergic stimulation might reduce these complications. In advanced Parkinson\u2019s
disease levodopa is still effective. In the treatment of this stage there are several advanced or
device-aided therapies: apomorphine pump, deep brain stimulation and levodopa\/carbidopa
intestinal gel. Levodopa\/carbidopa intestinal gel is an aqueous gel that can be delivered to
the jejunum via a percutaneous gastrojejunostomy tube which is connected to an infusion
pump dosing the levodopa gel continuously to the place of absorption. Levodopa\/carbidopa
gel infusion can be used as monotherapy, can be tested, can be used individually and this
therapy is reversible. Several clinical trials demonstrated that levodopa\/carbidopa intestinal
gel therapy is of long-term benefit, improves the quality of life of the patients and can reduce
motor fluctuation and dyskinesia.<\/p>\n
Keywords: advanced Parkinson\u2019s disease, motor and non-motor fluctuation, dyskinesia,
continuous dopaminergic stimulation, advanced therapy, levodopa\/carbidopa intestinal gel<\/p>\n
[\/et_pb_toggle][et_pb_blurb title=”Oral disease-modifying agents in relapsing-remitting multiple sclerosis” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/iljicsov_2015_dec.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-4-szam\/iljicsov_2015_dec.pdf” link_option_url_new_window=”on”]<\/p>\n
Anna Iljicsov, Zsuzsanna\u00a0 P\u00e1l and Magdolna Sim\u00f3<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
In relapsing-remitting multiple sclerosis, only parenteral immunomodulatory treatments
existed for 15 years, until 2010. In recent years, novel disease-modifying agents became available with new mechanisms of action and oral application, which expanded therapeutic options.
Thus, when making therapeutic decisions, more and new aspects should be considered, and
the daily practice of patient management has been changed due to the different profile of
possible side-effects. The authors review the mechanism of action, pharmacokinetics, studies
regarding efficacy, side-effects of first- and second line oral disease-modifying treatments and
provide practical guide of their everyday usage.<\/p>\n
Keywords: relapsing-remitting multiple sclerosis, disease-modifying treatment, oral therapy<\/p>\n
[\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/05\/borito_honlapra_kicsi.jpg” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ box_shadow_style=”preset3″][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
VOLUME 17, ISSUE 4, DECEMBER 2015J\u00e1nos K\u00e1lm\u00e1nIn memoriam Dr. Szil\u00e1rd J\u00e1nos Andr\u00e1s K\u00e1lm\u00e1n J\u00e1nos 2015. okt\u00f3ber 16-\u00e1n elhunyt Dr. Szil\u00e1rd J\u00e1nos Andr\u00e1s, az orvostudom\u00e1nyok kandid\u00e1tusa, emeritus professzor, a Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Egyetem rektora, az Ideg- \u00e9s Elmegy\u00f3gy\u00e1szati Klinika kor\u00e1bbi tansz\u00e9kvezet\u0151 egyetemi tan\u00e1ra, a Magyar Pszichi\u00e1triai T\u00e1rsas\u00e1g alap\u00edt\u00f3 tagja, a pszichi\u00e1triai szakma \u00f6n\u00e1ll\u00f3sod\u00e1s\u00e1nak, a szoci\u00e1lpszichi\u00e1triai \u00e9s […]<\/p>\n","protected":false},"author":4,"featured_media":48307,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[60],"project_tag":[],"class_list":["post-49312","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-2015-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=49312"}],"version-history":[{"count":7,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49312\/revisions"}],"predecessor-version":[{"id":49542,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49312\/revisions\/49542"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48307"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=49312"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=49312"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=49312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}