[et_pb_section fb_built=”1″ _builder_version=”3.22.7″ custom_padding=”||5px|||”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”3.22.3″ custom_padding=”24px|0px|25px|0px|false|false”][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Editoral in Hungarian ” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/szerklevel_nph_2015_jun.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/szerklevel_nph_2015_jun.pdf” link_option_url_new_window=”on”]<\/p>\n
S\u00e1ndor Kalm\u00e1r<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
Bizony\u00edtott t\u00e9ny, hogy a pszichi\u00e1triai betegs\u00e9gek jelent\u0151s r\u00e9sze el\u0151sz\u00f6r a serd\u00fcl\u0151korban \u00e9s a fiatal feln\u0151tt korban manifeszt\u00e1l\u00f3dik, ami azt jelzi, hogy a sz\u00fclet\u00e9st\u0151l a feln\u0151tt\u00e9 v\u00e1l\u00e1sig tart\u00f3 \u00faton sz\u00e1mos hi\u00e1nyoss\u00e1ggal \u00e9s hib\u00e1val kell sz\u00e1molni, amelyek sem felismer\u00e9sre, sem megfelel\u0151 kezel\u00e9sre nem ker\u00fclnek. A sz\u00fclet\u00e9st\u0151l a feln\u0151tt\u00e9 v\u00e1l\u00e1s folyamat\u00e1nak (szubjekt\u00edv) pszichol\u00f3giai le\u00edr\u00e1sait j\u00f3l ismerj\u00fck, azonban az egyes fejl\u0151d\u00e9si szakaszokr\u00f3l, azok eg\u00e9szs\u00e9ges \u00e9s k\u00f3ros elv\u00e1ltoz\u00e1sainak idegrendszeri morfol\u00f3giai, biok\u00e9miai \u00e9s funkcion\u00e1lis elt\u00e9r\u00e9seir\u0151l kev\u00e9s, a gyakorlatban hasznos\u00edthat\u00f3 term\u00e9szettudom\u00e1nyos, organikus neurol\u00f3giai ismerettel rendelkez\u00fcnk. A rendk\u00edv\u00fcl gazdag \u00e9s sz\u00ednes pszichopatol\u00f3giai, pszichoszomatikus \u00e9s magatart\u00e1si t\u00fcnetr\u0151l sok ismeret\u00fcnk van, de ezek organikus eredete pontosan nem ismert, \u00edgy azok hat\u00e9kony befoly\u00e1sol\u00e1s\u00e1ra, kezel\u00e9s\u00e9re a legt\u00f6bb esetben nincs lehet\u0151s\u00e9g\u00fcnk. A k\u00fcl\u00f6nb\u00f6z\u0151 pszichol\u00f3giai le\u00edr\u00e1sok egy\u00e1ltal\u00e1n nem foglalkoznak sem a norm\u00e1lis fejl\u0151d\u00e9s, sem a k\u00f3ros elv\u00e1ltoz\u00e1sok idegrendszeri eredet\u00e9vel \u00e9s okaival. Az senki el\u0151tt nem k\u00e9ts\u00e9ges, hogy minden magatart\u00e1snak, pszichopatol\u00f3giai \u00e9s magatart\u00e1s t\u00fcnetnek a h\u00e1tter\u00e9ben valamilyen organikus neurol\u00f3giai, biok\u00e9miai elv\u00e1ltoz\u00e1s tal\u00e1lhat\u00f3, de ezek gy\u00f3gyszeres kezel\u00e9se ma m\u00e9g a mindennapi gy\u00f3gy\u00edt\u00e1s sor\u00e1n nem biztos\u00edtott.<\/p>\n<\/div>\n
[\/et_pb_toggle][et_pb_blurb title=”The temporal accuracy of agomelatine administration and comparison of antidepressant effect of agomelatine and escitalopram in major depression, a retrospective investigation at a psychiatric outpatient clinic” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/domotor_nph_2015_jun.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/domotor_nph_2015_jun.pdf” link_option_url_new_window=”on”]<\/p>\n
Eszter\u00a0 D\u00f6m\u00f6t\u00f6r and \u00c9va Fogarassy Herm\u00e1nn\u00e9<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
Aim: The assessment of antidepressant efficacy of agomelatine, a new chronobiological type
of antidepressant as a function of the temporal accuracy of administration, compared to
the antidepressive effect of escitalopram. Methods: In our retrospective study at the end of
a 12-week treatment improvement rates were analysed in all depressed patients attending
our ourpatient clinic receiving agomelatine (25 or 50 mg daily) or escitalopram (10 or 20 mg
daily) monotherapy initiated between 01. 03. 2014 and 01. 03. 2015 Follow-up interviews were
conducted to evaluate temporal accuracy of agomelatine administration in the evenings and
we divided our group into accurately and inaccurately administered agomelatine groups.
Results: In the inaccurately administered agomelatine group (n=16) after 12 weeks 7 patients
(43.7 %) showed no improvement, 7 patients showed response (43.7%), and two entered remission (12.5%). In the accurately administered agomelatine group (n=63) 18 patients showed
no improvement (28.6%), 15 were responders (23.8%) and 30 patients entered remission
(47.6%). Regarding the improvement rates there was a significant difference between the two
agomelatine groups (p=0.034). Comparing the 12-week improvement ratio of the accurate
agomelatine group to all patients in the outpatient practice (n=62) receiving escitalopram
(30 vs 29 remitters, 15 vs 15 responders, and 18 vs 18) no difference in improvement rates
was shown between groups (p= 0.982). Conclusions: Our results show for the first time that
the accuracy of administration of evening agomelatine medication has a crucial importance
in terms of efficacy, furthermore confirm the results of previous international clinical trials
that the antidepressant agomelatine exerts the same strength of antidepressant effect as the
clinically proven escitalopram.<\/p>\n
Keywords: agomelatine, escitalopram, major depression<\/p>\n
[\/et_pb_toggle][et_pb_blurb title=”An update on the conceptual and classification issues of anxiety, its neuroanatomy and problems of anxiolytic drug discovery” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/faludi_nph_2015_jun.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/faludi_nph_2015_jun.pdf” link_option_url_new_window=”on”]<\/p>\n
G\u00e1bor Faludi, X\u00e9nia Gonda, and P\u00e9ter D\u00f6me<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
Anxiety disorders are highly prevalent psychiatric diseases. In this short review we provide an
overview of concepts of fear, anxiety and anxiety disorders. In addition, based on the recent
literature, neuroanatomical structures involved in anxiety and functional\/structural changes
of these structures in anxiety disorders are also discussed. Furthemore, the pitfalls of anxiolytic
drug discovery is also concerned in the paper.<\/p>\n
Keywords: anxiety; neurobiology; neuroimaging; drug discovery<\/p>\n
[\/et_pb_toggle][et_pb_blurb title=”Antidepressants, stressors and the serotonin 1A receptor” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/kirilly_nph_2015_jun.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/kirilly_nph_2015_jun.pdf” link_option_url_new_window=”on”]<\/p>\n
Eszter Kirilly, X\u00e9nia Gonda, and Gy\u00f6rgy Bagdy<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
5-HT1A receptor is a receptor of surprises. Buspirone, an anxiolytic drug with a then yet unidentified mechanism of action had been marketed for years when it was discovered that it
is a 5-HT1A partial agonist. Several more years had to pass before it was accepted that this
receptor plays the key role in the action mechanism of buspirone. This was followed by
further surprises. It was discovered that in spite of its anxiolytic effect buspirone activates
the hypothalamic-pituitary-adrenal (HPA) stress axis, furthermore, it increases peripheral
noradrenaline and adrenaline concentration via a central mechanism. Thus activation of this
receptor leads to ACTH\/corticosterone and catecholamine release and also increases betaendorphine, oxytocin and prolactin secretion while decreasing body temperature, increasing
food uptake, eliciting characteristic behavioural responses in rodents and also playing a role
in the development of certain types of epilepsy. Human genetic studies revealed the role of
5-HT1A receptors in cognitive processes playing a role in the development of depression such
as impulsiveness or response to environmental stress. This exceptionally wide spectrum of
effects is attributable to the presence of 5-HT1A receptors in serotonergic as well as other, for
example glutamatergic, cholinergic, dopaminergic and noradrenergic neurons. The majority of the effects of 5-HT1A receptors is manifested via the mediation of Gi
proteins through
the hyperpolarisation or inhibition of the neuron carrying the receptor. 5-HT1A receptors on
serotonergic neurons can be found in the somatodendritic area and play a significant role in
delaying the effects of antidepressants which is an obvious disadvantage. Therefore the newest serotonergic antidepressants including vilazodone and vortioxetine have been designed
to possess 5-HT1A receptor partial agonist properties. In the present paper we focus primarily
on the role of 5-HT1A receptors in stress and antidepressant response.<\/p>\n
Keywords: 5-HT1A receptor, stress, antidepressants, anxiolytics, HPA-axis, vilazodone,
vortioxetine<\/p>\n
[\/et_pb_toggle][et_pb_blurb title=”The most important obstacles of the Development of Hungarian Psychiatry” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/kalmar_nph_2015_jun.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/kalmar_nph_2015_jun.pdf” link_option_url_new_window=”on”]<\/p>\n
S\u00e1ndor Kalm\u00e1r<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
A quarter of a century ago the change of the political system in Hungary precipitated a serious value-crisis and caused a lot of harmful effects in nurturing and the development of
psychiatry. The author establishes that the attack against psychiatry is more intensive than
previously but neither the education and health management nor the psychiatric leadership
could cope with these difficulties. It can\u2019t be denied that the foundation of lifelong mental
health begins in the early life years and about 75% of the first Mental Disorder manifests in
adolescence and youth. We are not able to ensure the special rights of every child according
to the Hungarian Constitution and the Declaration of the Rights of the Child by the United
Nations. The large inequalities within the country, the lack of paramount mental education
and nurturing, the lack of essential, consistent eternal values, the lack of required psychiatric
care system are huge obstacles of the development of healthy individual and leads to selfdestructive behaviour and several, serious physical and mental disorders. The purpose of the
author is to call psychiatrists\u2019 attention to the main obstacles of the development of Hungarian
Psychiatric Care System. The main obstacles of the present psychiatric care system:
1. Unclarified notions, confusion of ideas.
2. Somatic, neurologic, mental, cultural-social and spiritual ignorance.
3. Lack of organization in Mental Education and Psychiatric Care System.
4. Value-crisis in our society despite the fact that the \u201dCouncil of Wise Men\u201d created a \u201dScale
of the Essential Consistent Eternal Values\u201d for the Hungarian Education System in 2008.
5. Lack of mental health prevention both in education system and health care system. There
is no teaching of hygiene lessons in the Hungarian schools.
6. Negligence and selfishness among the population.
7. Disinterest among competent authorities.
8. Leaving the most important possibilities out of consideration.
The author establishes that the elimination of the above mentioned obstacles, the high standard of psychiatric care system, – especially the child psychiatric care system \u2013 and paramount
mental education are extraordinarily important to prevent most psychiatric disorders and help
the development of healthy and happy people. If human individuals are the most important
ones in our society, if we eliminate the main obstacles of the development of psychiatry, we
ensure to improve Hungarian psychiatry again, we shall be able to say that \u201dthe spiritual light
is shining through the windows of every house\u201d, and our work will not be a quixotic struggle
or \u201dtilting at windmills\u201d.<\/p>\n
Keywords: crisis of psychiatry, mental, cultural, spiritual ignorance, disinterest, lack of mental
prevention, teaching of hygiene lessons, value crisis, obstacles and possibilities.<\/p>\n
[\/et_pb_toggle][et_pb_blurb title=”The importance of early diagnosis and intervention in children diagnosed with reading disorder. Case studies” url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/toro_nph_2015_jun.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xvii-evfolyam-2-szam\/toro_nph_2015_jun.pdf” link_option_url_new_window=”on”]<\/p>\n
Krisztina T\u00f6r\u0151 and Judit Bal\u00e1zs<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
Reading Disorder (RD) belongs to Specific Learning Disorders within the chapter of Neurodevelopmental Disorders in the Diagnostic and Statistic Manual of Mental Disorders 5th edition.
Previous research shows that the time of the diagnosis of RD \u2013 early (before starting school) or
late \u2013 has a great impact on the prognosis. In the current paper we present the cases of two
children diagnosed with RD. Our cases demonstrate that if RD is diagnosed in early childhood,
the child\u2019s and his\/her family\u2019s quality of life can be influenced in a positive direction, while
late recognition of RD might influence the child\u2019s and the family\u2019s quality of life negatively.
For these reasons it is important that experts recognize RD in time, start appropriate treatment
and give proper support to children diagnosed with RD and their families.<\/p>\n
Keywords: reading disorder, dyslexia, quality of life, diagnostics, therapy<\/p>\n
[\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/05\/b1_nph_2015_jun_kicsi.jpg” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ box_shadow_style=”preset3″][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
VOLUME 17, ISSUE 2, JUNE 2015S\u00e1ndor Kalm\u00e1rA neurol\u00f3giai \u00e9s neuropszichopharmakol\u00f3giai kutat\u00e1sok jelent\u0151s\u00e9ge a szem\u00e9lyis\u00e9gfejl\u0151d\u00e9s sor\u00e1n tapasztalt elv\u00e1ltoz\u00e1sok meg\u00e9rt\u00e9se \u00e9s kezel\u00e9se szempontj\u00e1b\u00f3lKalm\u00e1r S\u00e1ndorBizony\u00edtott t\u00e9ny, hogy a pszichi\u00e1triai betegs\u00e9gek jelent\u0151s r\u00e9sze el\u0151sz\u00f6r a serd\u00fcl\u0151korban \u00e9s a fiatal feln\u0151tt korban manifeszt\u00e1l\u00f3dik, ami azt jelzi, hogy a sz\u00fclet\u00e9st\u0151l a feln\u0151tt\u00e9 v\u00e1l\u00e1sig tart\u00f3 \u00faton sz\u00e1mos hi\u00e1nyoss\u00e1ggal \u00e9s hib\u00e1val kell sz\u00e1molni, […]<\/p>\n","protected":false},"author":4,"featured_media":48305,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[60],"project_tag":[],"class_list":["post-49314","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-2015-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=49314"}],"version-history":[{"count":8,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49314\/revisions"}],"predecessor-version":[{"id":49671,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49314\/revisions\/49671"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48305"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=49314"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=49314"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=49314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}