[et_pb_section fb_built=”1″ _builder_version=”3.22.7″ custom_padding=”||5px|||”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”3.22.3″ custom_padding=”24px|0px|25px|0px|false|false”][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Preface” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/eloszo.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”4.6.6″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/eloszo.pdf” link_option_url_new_window=”on”]<\/p>\n
Gaszner P\u00e9ter<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
We have published a thematic journal on schizophrenia in the December 2011 issue of Neuropsychopharmacologia Hungarica, already thinking of starting a new tradition, since many high-impact,
peer-reviewed scientific journals publish special editions to investigate hot research topics in-depth.
This December we aim to follow this tradition. As a guest editor, Gy\u00f6rgy Bagdy will aim at reviewing
the latest achievements of depression and anxiety research.
Besides its genetic background depression has been considered as a pandemic disease in Hungary.
Anxiety is thought to be a result of today\u2019s exhausting and stressful lifestyle on the basis of genetic
predisposition. Considering environmental and genetic interactions, Gy\u00f6rgy Bagdy has focused on
fundamental research and clinical observations in editing the present issue.
Phenomenology, genetic aetiology, functional changes in the brain and research of multifactorial
causes will further help us extend our knowledge of the etiopathogenesis of depression and anxiety
and promote effective treatment options.
The different subtypes of depression and its relationship to anxiety, anxiety as distinct entity and
different manifestations of multicultural psychiatry have always caused difficulty for clinicians. By
coordinating fundamental science and clinical research in the upcoming issue of Neuropsychopharmacologia Hungarica, we will not only focus on therapeutic outcomes, but also on the route of
developing our knowledge.<\/p>\n<\/div>\n
[\/et_pb_toggle][et_pb_blurb title=”A new clinical evidence-based gene-environment interaction model of depression” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/bagdy_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/bagdy_web.pdf” link_option_url_new_window=”on”]<\/p>\n
Gyorgy Bagdy, Gabriella Juhasz and Xenia Gonda<\/p>\n
[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n
In our current understanding of mood disorders, the role of genes is diverse including the mediation of the effects of provoking and protective factors. Different or partially overlapping gene sets play a major role in the development of personality traits including also affective temperaments, in the mediation of the effects of environmental factors, and in the interaction of these elements in the development of depression. Certain genes are associated with personality traits and temperaments including e.g., neuroticism, impulsivity, openness, rumination and extroversion. Environmental factors consist of external (early and provoking life events, seasonal changes, social support etc.) and internal factors (hormones, biological rhythm generators, comorbid disorders etc). Some of these environmental factors, such as early life events and some prenatal events directly influence the development of personality traits and temperaments. In the NEWMOOD cohort polymorphisms of the genes of the serotonin transporter, 5-HT1A, 5-HT1B and 5-HT2A and endocannabinoid CB1 receptors, tryptophan hydroxylase, CREB1, BDNF and GIRK provide evidence for the involvement of these genes in the development of depression. Based on their role in this process they could be assigned to different gene sets. The role of certain genes, such as promoter polymorphisms of the serotonin transporter (5-HTTLPR) and CB1 receptor has been shown in more than one of the above factors. Furthermore, gene-gene interactions of these promoters associated with anxiety suggest the application of these polymorphisms in personalized medicine. In this review we introduce a new model including environmental factors, genes, trait and temperament markers based on human genetic studies.<\/p>\n
(Neuropsychopharmacol Hung 2012; 14(4): 213-220; doi: 10.5706\/nph201212001)<\/em><\/p>\n Keywords:<\/strong>\u00a05-HTTLPR, gene-environment interaction, evidence-based, personalized treatment, depression, neuroticism, life events, personality trait, temperament<\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”Pharmaco- and therapygenetic aspects in the treatment of anxiety disorders beyond the serotonergic system: a brief review” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/faludi_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/faludi_web.pdf” link_option_url_new_window=”on”]<\/p>\n Gabor Faludi, Xenia Gonda, Gyorgy Bagdy\u00a0and Peter Dome<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n <\/p>\n<\/div>\n Anxiety disorders (ADs) are among the most frequent psychiatric disorders. In addition, key features of ADs include that they are among the earliest mental disorders to manifest and that their first specific treatment frequently occurs several years after the onset of symptoms. Although the heritability of anxiety disorders is well known, the genetic determination of response to different modalities (psycho- or pharmacotherapy) used in treatment of patients with ADs is lesser investigated. Several studies focused on the role of serotonergic genes in the etiopathology and pharmacotherapy of anxiety disorders, however, less attention was paid to variants of other genes. In this review we focus on the cytochrome P 450, BDNF, COMT, MAOA, EAA-3 transporter, dopamine transporter and dopamine receptor gene polymorphisms and their effects with respect to the pharmacogenetics of anxiety disorders. We discuss the current knowledge on pharmacogenetic\/therapygenetic aspects of anxiety disorders beyond the serotonergic system.<\/p>\n (Neuropsychopharmacol Hung 2012; 14(4): 221-229; doi: 10.5706\/nph201212002)<\/em><\/p>\n Keywords<\/strong>: anxiety disorders, pharmacogenetics, treatment response, anxiolytics, benzodiazepines, selective serotonin reuptake inhibitors, panic disorder, PTSD<\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”The role of purinergic signaling in depressive disorders” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/sperlagh_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/sperlagh_web.pdf” link_option_url_new_window=”on”]<\/p>\n Beata Sperlagh, Cecilia Csolle, Romeo D. Ando, Flora Goloncser, Agnes Kittel and Maria Baranyi<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n The purinergic signaling system consists of transporters, enzymes and receptors responsible for the synthesis, release, action and extracellular inactivation of adenosine 5\u2019-triphosphate (ATP) and its extracellular breakdown product adenosine. The actions of ATP are mediated ionotropic P2X and metabotropic P2Y receptor subfamilies, whilst the actions of adenosine are mediated by P1 adenosine receptors. Purinergic signaling pathways are widely expressed in the central nervous system (CNS) and participate in its normal and pathological functions. Among P2X receptors, the P2X7 receptor (P2rx7) has received considerable interest in both basic and clinical neuropsychiatric research because of its profound effects in animal CNS pathology and its potential involvement as a susceptibility gene in mood disorders. Although genetic findings were not always consistently replicated, several studies demonstrated that single nucleotide polymorphisms (SNPs) in the human P2X7 gene (P2RX7) show significant association with major depressive disorder and bipolar disorder. Animal studies revealed that the genetic knock-down or pharmacological antagonism leads to reduced depressive-like behavior, attenuated response in mania-model and alterations in stress reactivity. A potential mechanism of P2rx7 activation on mood related behavior is increased glutamate release, activation of extrasynaptic NMDA receptors and subsequent enduring changes in neuroplasticity. In addition, dysregulation of monoaminergic transmission and HPA axis reactivity could also contribute to the observed changes in behavior. Besides P2rx7, the inhibition of adenosine A1 and A2A receptors also mediate antidepressant-like effects in animal experiments. In conclusion, despite contradictions between existing data, these findings point to the therapeutic potential of the purinergic signaling system in mood disorders.<\/p>\n (Neuropsychopharmacol Hung 2012; 14(4): 231-238; doi: 10.5706\/nph201212003)<\/em><\/p>\n Keywords<\/strong>: ATP, adenosine, purinergic receptors, P2X7 receptor, depressive disorder,\u00a0 [\/et_pb_toggle][et_pb_blurb title=”Kynurenines in cognitive functions: their possible role in depression” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/plangar_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/plangar_web.pdf” link_option_url_new_window=”on”]<\/p>\n Imola Plangar, Zsofia Majlath\u00a0and Laszlo Vecsei<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n <\/p>\n<\/div>\n Depression can originate from changes in tryptophan availability, caused by activation of the kynurenine pathway (KP) as a result of inflammation. Alterations in the KP and the changing levels of its metabolites have recently been considered to be factors contributing to the pathogenesis of depression. The key molecular mediator which induces the conversion of tryptophan into kynurenine is indoleamine-2,3-dioxygenase. Following its activation, both the production of neurotoxic compounds and the diminished peripheral accessibility of tryptophan are regarded as essential steps in the pathophysiological processes. The aim of this review is to survey the role of the KP in depression and its relationships with cognitive functions.<\/p>\n (Neuropsychopharmacol Hung 2012; 14(4): 239-244; doi: 10.5706\/nph201212004)<\/em><\/p>\n Keywords<\/strong>: tryptophan metabolism, kynurenine pathway, cognitive deficit, depression<\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”The role of general practitioners in prevention of depression-related suicides” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/rihmer_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/rihmer_web.pdf” link_option_url_new_window=”on”]<\/p>\n Zoltan Rihmer, Peter Dome\u00a0and Xenia Gonda<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n Suicide is a ubiquitous phenomenon present in every country, and a function of the constellation of multiple risk and protective factors. The relatively low occurrence of attempted and completed suicide in the general community makes its research and consequentially prediction and prevention difficult, however, suicide events are common among psychiatric patients who contact their general practitioners some weeks or months before their suicidal act. Major depressive episode is the most common current psychiatric diagnosis among suicide victims and attempters (56-87%), and successful acute and long-term treatment of depression significantly reduces the risk of suicidal behaviour even in this high-risk population. The point prevalence of unipolar and bipolar major depressive episode encountered in general practice is more than 10% but unfortunately about half of these cases remain unrecognized, untreated or mistreated. As over half of all suicide victims contact their general practitioners within four weeks before their death, primary care physicians play a key role in suicide prediction and prevention. Several large-scale community studies show that education of general practitioners and other medical professionals on the recognition and appropriate pharmacotherapy of depression, particularly in combination with psycho-social interventions and public education significantly improves identification and treatment of depression and consequentially reduces the rate of completed and attempted suicide in the areas served by trained doctors.<\/p>\n (Neuropsychopharmacol Hung 2012; 14(4): 245-251; doi: 10.5706\/nph201212005)<\/em><\/p>\n Keywords<\/strong>: depression, General Practitioners, primary care, suicide, suicide attempt, suicide prevention<\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”Genetic aspects of the Stroop test” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/nanasi_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/nanasi_web.pdf” link_option_url_new_window=”on”]<\/p>\n Tibor N\u00e1n\u00e1si, Enik\u0151 R\u00f3zsa Katonai, M\u00e1ria\u00a0 Sasv\u00e1ri-Sz\u00e9kely and Anna Sz\u00e9kely<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n According to modern psychological theories the human life implies continuous development, the efficient solution of age-specific problems is necessary to the successful transition <\/span><\/p>\n (Neuropsychopharmacol Hung 2012; 14(4): 252-258; doi: 10.5706\/nph201212006)<\/em><\/p>\n <\/em><\/p>\n Keywords<\/strong>: Stroop test, candidate gene, polymorphism, dopamine, serotonin, acetylcholine, APOE \u03b54acetilkolin, APOE \u03b54<\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”Cultural differences in the development and characteristics of depression” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/juhasz_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/juhasz_web.pdf” link_option_url_new_window=”on”]<\/p>\n Gabriella Juhasz, Nora Eszlari, Dorottya Pap\u00a0and Xenia Gonda<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n Depression is a highly prevalent mental illness with increasing burden for the patients, their (Neuropsychopharmacol Hung 2012; 14(4): 259-265; doi: 10.5706\/nph201212007)<\/em><\/p>\n Keywords:<\/strong> depression, cross-country, cross-cultural, cross-ethnic, prevalence<\/p>\n [\/et_pb_toggle][et_pb_blurb title=”Life-cycles, psychopathology and suicidal behaviour” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/osvath_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/osvath_web.pdf” link_option_url_new_window=”on”]<\/p>\n P\u00e9ter Osv\u00e1th<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n According to modern psychological theories the human life implies continuous development, the efficient solution of age-specific problems is necessary to the successful transition <\/span><\/p>\n (Neuropsychopharmacol Hung 2012; 14(4): 266-272; doi: 10.5706\/nph201212008)<\/em><\/p>\n Keywords<\/strong>: life-cycle, psychosocial crisis, psychopatology, suicidal behaviour<\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”Beyond Structural Equation Modeling: model properties and effect size from a Bayesian viewpoint. An example of complex phenotype – genotype associations in depression” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/hullam_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/hullam_web.pdf” link_option_url_new_window=”on”]<\/p>\n Gabor Hullam, Gabriella Juhasz, Gyorgy Bagdy\u00a0and Peter Antal<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n Despite the rapid evolution of measurement technologies in biomedicine and genetics, most of the recent studies aiming to explore the genetic background of multifactorial diseases were only moderately successful. One of the causes of this phenomenon is that the bottleneck of genetic research is no longer the measurement process related to various laboratory technologies, but rather the analysis and interpretation of results. The commonly applied univariate methods are inadequate for exploring complex dependency patterns of multifactorial diseases which includes nearly all common diseases, such as depression, hypertension, and asthma. A comprehensive investigation requires multivariate modeling methods that enable the analysis of interactions between factors, and allow a more detailed interpretation of studies measuring complex phenotype descriptors. In this paper we discuss various aspects of multivariate modeling through a case study analyzing the effect of the single nucleotide polymorphism rs6295 in the HTR1A gene on depression and impulsivity. We overview basic concepts related to multivariate modeling and compare the properties of two investigated modeling techniques: Structural Equation Modeling and Bayesian network based learning algorithms. The resulting models demonstrate the advantages of the Bayesian approach in terms of model properties and effect size as it allows coherent handling of the weakly significant effect of rs6295. Results also confirm the mediating role of impulsivity between the SNP rs6295 of HTR1A and depression.<\/p>\n (Neuropsychopharmacol Hung 2012; 14(4): 273-284; doi: 10.5706\/nph201212009)<\/em><\/p>\n Keywords<\/strong>: Bayesian network based learning algorithm, structural equation modeling, effect size, multivariate statistical methods, systems based modeling, depression, impulsivity<\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_blurb title=”Association between the COMT gene and rumination in a Hungarian sample” url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/pap_web.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xiv-evfolyam-4-szam\/pap_web.pdf” link_option_url_new_window=”on”]<\/p>\n Dorottya Pap, Gabriella Juhasz\u00a0and Gyorgy Bagdy<\/p>\n [\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n <\/p>\n<\/div>\n Introduction<\/strong>: Rumination is a multidimensional trait which is a proven risk factor in the vulnerability to depression. The aim to identify the main risk genes for depression in addition to the gene-environment interactions pointed to the importance of intermediate phenotypes, like rumination, to improve our understanding of the biological mechanisms of depression. Catechol-O-Methyltransferase (COMT) gene is extensively investigated in depression with contradictory results but its association with rumination, as an intermediate phenotype in depression, has not been investigated yet.\u00a0Methods<\/strong>: In our study, four tagging SNPs in the COMT gene (rs933271, rs740603, rs4680, rs4646316) were genotyped in a nonclinical Hungarian sample (n=939). We investigated the association between the COMT gene and rumination scores measured by the Ruminative Response Scale using haplotype trend regression.\u00a0Results<\/strong>: We found a significant association between COMT haplotypes and rumination scores (p=0.013) but no significant association was apparent between the functional Val158Met polymorphism (rs4680) and rumination in any genetic model.\u00a0Discussion<\/strong>: Variations in the COMT gene exert complex effects on susceptibility to depression involving intermediate phenotypes, such as rumination and also impulsivity, as we previously demonstrated. Both rumination and impulsivity represent maladaptive cognitive styles that can lead to depressive state by influencing the response to negative life events and life stressors. In conclusion, our findings provide evidence that in addition to other genes, COMT also has a significant role in the development of depression, and demonstrate that analysing the complex phenotype associations of genes by haplotype tagging is a powerful method.<\/p>\n (Neuropsychopharmacol Hung 2012; 14(4): 285-292; doi: 10.5706\/nph201212010)<\/em><\/p>\n Keywords<\/strong>: COMT, rumination, depression, genetics<\/p>\n<\/div>\n [\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/05\/cimlap_december_2012_web.jpg” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ box_shadow_style=”preset3″][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" VOLUME 14, ISSUE 4, DECEMBER 2012Gaszner P\u00e9ter We have published a thematic journal on schizophrenia in the December 2011 issue of Neuropsychopharmacologia Hungarica, already thinking of starting a new tradition, since many high-impact,peer-reviewed scientific journals publish special editions to investigate hot research topics in-depth.This December we aim to follow this tradition. As a guest editor, […]<\/p>\n","protected":false},"author":4,"featured_media":48320,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[63],"project_tag":[],"class_list":["post-49324","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-2012-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=49324"}],"version-history":[{"count":8,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49324\/revisions"}],"predecessor-version":[{"id":49690,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49324\/revisions\/49690"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48320"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=49324"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=49324"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=49324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
bipolar disorder<\/p>\n<\/div>\n\u00a0<\/h4>\n
of age-periods. The phases of transition are very vulnerable against the accidental stressors
and negative life-events. Thus the problem-solving capacity may run out, which impairs
chance of the successful coping with stressful events. It may result in some negative consequences, such as different psychopathological symptoms (depression, anxiety, psychosis) or
even suicidal behaviour. For that reason we have to pay special attention to the symptoms
of psychological crisis and the presuicidal syndrome. In certain life-cycle transitions (such as
adolescent, middle or elderly age) the personality has special vulnerability to the development of psychological and psychopathological problems. In this article the most important
features of life-cycles and psychopathological symptoms are reviewed. The developmental
and age-specific characteristics have special importance in understanding the background of
the actual psychological crisis and improving the efficacy of the treatment. Using the complex
bio-psycho-socio-spiritual approach not only the actual psychopatological problems, but the
individual psychological features can be recognised. Thus the effective treatment relieves not
only the actual symptoms, but will increase the chance for solving further crises.<\/span><\/p>\n<\/h4>\n
families and society as well. In spite of its increasing importance, we still do not have complete understanding either of the phenomenology or the etiopathological background of
depression, and cross-country, cross-ethnic and cross-cultural differences in the prevalence
and symptomatic manifestation of depression further obscure this picture. Culturally-related
features of depressive illness are gaining more importance in clinical practice with the increasing migration trends worldwide. In spite of the differences replicated in multiple studies, no
exhaustive explanations are offered so far. In the present paper we describe the most consistently replicated findings concerning the most important cross-national differences in the
rates and characteristics of depression with a short comment on possible background factors.<\/p>\n
of age-periods. The phases of transition are very vulnerable against the accidental stressors
and negative life-events. Thus the problem-solving capacity may run out, which impairs
chance of the successful coping with stressful events. It may result in some negative consequences, such as different psychopathological symptoms (depression, anxiety, psychosis) or
even suicidal behaviour. For that reason we have to pay special attention to the symptoms
of psychological crisis and the presuicidal syndrome. In certain life-cycle transitions (such as
adolescent, middle or elderly age) the personality has special vulnerability to the development of psychological and psychopathological problems. In this article the most important
features of life-cycles and psychopathological symptoms are reviewed. The developmental
and age-specific characteristics have special importance in understanding the background of
the actual psychological crisis and improving the efficacy of the treatment. Using the complex
bio-psycho-socio-spiritual approach not only the actual psychopatological problems, but the
individual psychological features can be recognised. Thus the effective treatment relieves not
only the actual symptoms, but will increase the chance for solving further crises.\u00a0<\/span><\/p>\n