{"id":49332,"date":"2010-12-29T10:07:28","date_gmt":"2010-12-29T10:07:28","guid":{"rendered":"https:\/\/mppt.hu\/project\/2010-december-xii-evfolyam-4-szam\/"},"modified":"2020-10-29T15:54:47","modified_gmt":"2020-10-29T15:54:47","slug":"2010-december-xii-evfolyam-4-szam","status":"publish","type":"project","link":"https:\/\/mppt.hu\/en\/project\/2010-december-xii-evfolyam-4-szam\/","title":{"rendered":"Volume 12, Issue 4, December 2010"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”3.22.7″ custom_padding=”||5px|||”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n

Volume 12, Issue 4, December 2010<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”3.22.3″ custom_padding=”24px|0px|25px|0px|false|false”][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Editoral in Hungarian ” url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_szerk_level_2010dec_20110104.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_szerk_level_2010dec_20110104.pdf” link_option_url_new_window=”on”]<\/p>\n

G\u00e1bor Csukly<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

Az elm\u00falt \u00e9vek sor\u00e1n a pszichi\u00e1triai t\u00e9m\u00e1j\u00fa kutat\u00e1sok \u00e9s tudom\u00e1nyos k\u00f6zlem\u00e9nyek sz\u00e1ma robban\u00e1sszer\u0171en megn\u00f6vekedett. Ahogy azt egy kor\u00e1bbi szerkeszt\u0151s\u00e9gi lev\u00e9lben olvashattuk, ilyen nagy mennyis\u00e9g\u0171 eredm\u00e9ny k\u00f6vet\u00e9se szinte lehetetlen feladat, ez\u00e9rt is n\u00f6vekszik a meta-anal\u00edzisek jelent\u0151s\u00e9ge.
\u00a0\u00a0\u00a0\u00a0 Szembet\u0171n\u0151 azonban, hogy a publik\u00e1lt vizsg\u00e1latok nagyobb r\u00e9sze keresztmetszeti k\u00e9pet ad, vagy egy r\u00f6videbb id\u0151szakr\u00f3l ny\u00fajt inform\u00e1ci\u00f3kat. Ez\u00e9rt szembes\u00fcl\u00fcnk azzal a jelens\u00e9ggel, hogy a nagy mennyis\u00e9g\u0171 publik\u00e1ci\u00f3 ellen\u00e9re van n\u00e9h\u00e1ny k\u00e9rd\u00e9s, melyekre r\u00e1keresve kev\u00e9s hivatkoz\u00e1st tal\u00e1lunk a nemzetk\u00f6zi publik\u00e1ci\u00f3s adatb\u00e1zisokban. P\u00e9ld\u00e1ul, ha arra vagyunk k\u00edv\u00e1ncsiak, hogy mely antidepressz\u00e1ns szed\u00e9se mellett jelentkezik a legkevesebb visszaes\u00e9s 20 \u00e9v alatt, vagy jav\u00edt-e a visszaes\u00e9si r\u00e1t\u00e1n, ha k\u00f6zben kognit\u00edv pszichoter\u00e1pi\u00e1t is alkalmazunk, kev\u00e9s tal\u00e1latot kapunk a Pubmed-en.\u00a0
\u00a0\u00a0\u00a0\u00a0 Feltehet\u00fcnk szinte b\u00e1rmilyen k\u00e9rd\u00e9st az irodalomkutat\u00e1s sor\u00e1n, ha n\u00f6velni kezdj\u00fck a vizsg\u00e1lat id\u0151tartam\u00e1t, a tal\u00e1latok sz\u00e1ma drasztikusan esni kezd betegs\u00e9gt\u0151l \u00e9s t\u00e9m\u00e1t\u00f3l f\u00fcggetlen\u00fcl. A jelens\u00e9g magyar\u00e1zata t\u00f6bb t\u00e9nyez\u0151re vezethet\u0151 vissza, de alapvet\u0151en m\u00f3dszertani neh\u00e9zs\u00e9gek \u00e9s financi\u00e1lis okok \u00e1llnak a h\u00e1tt\u00e9rben. El\u0151bbiekre j\u00f3 p\u00e9lda, hogy hossz\u00fa id\u0151 alatt jelent\u0151sen v\u00e1ltozik a gy\u00f3gyszerel\u00e9s \u00e9s v\u00e1ltoznak a betegs\u00e9gcsoportok is (DSM \u00e9s BNO v\u00e1ltoz\u00e1sai), mely nagyban megnehez\u00edti a v\u00e9gs\u0151 ki\u00e9rt\u00e9kelhet\u0151s\u00e9get. Mivel tudom\u00e1nyos ismereteink alapvet\u0151en v\u00e1ltoznak, ez\u00e9rt a vizsg\u00e1lat elej\u00e9n m\u00e9rt \u00e9s fontosnak tartott v\u00e1ltoz\u00f3kr\u00f3l k\u00f6nnyen kider\u00fclhet, hogy nem relev\u00e1nsak az adott k\u00e9rd\u00e9sben, m\u00edg \u00fajabb ismeretek olyan v\u00e1ltoz\u00f3k bevon\u00e1s\u00e1t tenn\u00e9k sz\u00fcks\u00e9gess\u00e9, melyek nem ker\u00fcltek bele a vizsg\u00e1lati tervbe. Tov\u00e1bb bonyol\u00edtja a ki\u00e9rt\u00e9kelhet\u0151s\u00e9get, hogy ilyen hossz\u00fa id\u0151 alatt a betegek egy komoly r\u00e9sze kiesik a vizsg\u00e1latb\u00f3l, m\u00e9ghozz\u00e1 sokszor pontosan a legrosszabb kimenetel\u0171 esetek, ami az eredm\u00e9nyeket er\u0151sen torz\u00edthatja. V\u00e9gezet\u00fcl \u00e9rdemes m\u00e9g hozz\u00e1tenni, hogy a vizsg\u00e1latot v\u00e9gz\u0151 szem\u00e9lyzet v\u00e1ltoz\u00e1sa is befoly\u00e1solhatja az eredm\u00e9nyeket.
\u00a0\u00a0\u00a0\u00a0 M\u00e1sr\u00e9szr\u0151l ezek a vizsg\u00e1latok rendk\u00edv\u00fcl dr\u00e1g\u00e1k is, aminek egyenes k\u00f6vetkezm\u00e9nye, hogy 10, 15 vagy 20 \u00e9ves ut\u00e1nk\u00f6vet\u00e9ses vizsg\u00e1latot nem igaz\u00e1n \u201e\u00e9ri meg\u201d v\u00e9gezni. A tudom\u00e1nyos vizsg\u00e1latok jelent\u0151s r\u00e9sz\u00e9t gy\u00f3gyszerkutat\u00f3 c\u00e9gek szponzor\u00e1lj\u00e1k, sz\u00e1mukra k\u00f6telez\u0151 a szerek r\u00f6vid \u00e9s k\u00f6z\u00e9pt\u00e1v\u00fa biztons\u00e1goss\u00e1g\u00e1t \u00e9s hat\u00e9konys\u00e1g\u00e1t bizony\u00edtani, ott minden egyes tov\u00e1bbi vizit s\u00falyos doll\u00e1rokba ker\u00fcl: az FDA \u00e1ltal t\u00e1masztott krit\u00e9riumok a biztons\u00e1goss\u00e1g \u00e9s hat\u00e9konys\u00e1g tekintet\u00e9ben rendk\u00edv\u00fcl szigor\u00faak, egy-egy gy\u00f3gyszer kifejleszt\u00e9se ez\u00e9rt m\u00e1r \u00edgy is rendk\u00edv\u00fcl dr\u00e1ga. Itt az igaz\u00e1n hossz\u00fat\u00e1v\u00fa, 10-20 \u00e9vet fel\u00f6lel\u0151 vizsg\u00e1latok nem j\u00f6hetnek sz\u00f3ba, \u00e9s persze nem is elv\u00e1rhat\u00f3ak. A vizsg\u00e1latok m\u00e1sik r\u00e9sze egyetemi kutat\u00f3helyeken t\u00f6rt\u00e9nik, ahol az eredm\u00e9nyess\u00e9g fontos mutat\u00f3ja a nemzetk\u00f6zi tudom\u00e1nyos foly\u00f3iratokban publik\u00e1lt k\u00f6zlem\u00e9ny, ennek alapj\u00e1n tudnak a kutat\u00f3helyek p\u00e1ly\u00e1zni nemzeti vagy nemzetk\u00f6zi \u201egrant\u201d-okra, ezzel tov\u00e1bbi m\u0171k\u00f6d\u00e9s\u00fcket fenntartani. \u00cdgy azt\u00e1n ha egy kutat\u00f3hely fenn akarja tartani m\u0171k\u00f6d\u00e9s\u00e9t, musz\u00e1j figyelnie arra, hogy a befektetett munka \u00e9s p\u00e9nz mihamarabb megt\u00e9r\u00fclj\u00f6n, a kutat\u00e1sb\u00f3l gyorsan publik\u00e1lt eredm\u00e9ny legyen. Ebben a rendszerben 20 \u00e9ves ut\u00e1nk\u00f6vet\u00e9ses vizsg\u00e1latot tervezni luxus, mely csak kev\u00e9s kutat\u00f3hely sz\u00e1m\u00e1ra lehets\u00e9ges.\u00a0
\u00a0\u00a0\u00a0\u00a0 Milyen lehet\u0151s\u00e9g ad\u00f3dhat m\u00e9gis, mit lehetne tenni annak \u00e9rdek\u00e9ben, hogy t\u00f6bb hossz\u00fat\u00e1v\u00fa vizsg\u00e1lat k\u00e9sz\u00fclj\u00f6n? A fenti helyzeten maguk a kutat\u00f3helyek aligha tudnak v\u00e1ltoztatni, es\u00e9lye egyed\u00fcl tal\u00e1n\u00a0
a fels\u0151oktat\u00e1si int\u00e9zm\u00e9nyeknek maguknak illetve azoknak a hazai vagy k\u00fclf\u00f6ldi k\u00f6zponti szerveknek van, akik a p\u00e1ly\u00e1zatokat ki\u00edrj\u00e1k. Nemzetk\u00f6zi szinten j\u00f3 lehet\u0151s\u00e9g lenne a m\u00e1r l\u00e9tez\u0151 nagy eg\u00e9szs\u00e9g\u00fcgyi adatb\u00e1zisokat kutat\u00f3k sz\u00e1m\u00e1ra el\u00e9rhet\u0151v\u00e9 tenni, \u00e9s olyan kutat\u00e1si projekteket finansz\u00edrozni, amelyek az ezeken az adatb\u00e1zisokon t\u00f6rt\u00e9n\u0151 munk\u00e1hoz a megfelel\u0151 infrastrukt\u00far\u00e1t megteremtik. Tov\u00e1bbi \u00e9rdekes lehet\u0151s\u00e9g lenne m\u00e9g, ha a tudom\u00e1nyos foly\u00f3iratok k\u00f6telez\u0151v\u00e9 tenn\u00e9k a vizsg\u00e1latok adatainak valamilyen szabv\u00e1nyos form\u00e1ban val\u00f3 felt\u00f6lt\u00e9s\u00e9t k\u00f6zponti adatb\u00e1zisokba, mint ahogyan azt az FDA is k\u00e9ri, mindez rendk\u00edv\u00fcli m\u00e9rt\u00e9kben megk\u00f6nny\u00edten\u00e9 a metaanal\u00edzisek elv\u00e9gz\u00e9s\u00e9t. Orsz\u00e1gon bel\u00fcl lehets\u00e9ges v\u00e1ltoztat\u00e1si pont azon szoftverek megv\u00e1ltoztat\u00e1sa lenne, melyeken kereszt\u00fcl az adatbevitel t\u00f6rt\u00e9nik a mindennapi ell\u00e1t\u00e1s sor\u00e1n, az itt alkalmazott fejleszt\u00e9sek jelent\u0151sen cs\u00f6kkenthetn\u00e9k a hossz\u00fat\u00e1v\u00fa ut\u00e1nk\u00f6vet\u00e9ses, illetve k\u00e9s\u0151bb a retrospekt\u00edv vizsg\u00e1latok k\u00f6lts\u00e9geit.
\u00a0\u00a0\u00a0\u00a0 Val\u00f3j\u00e1ban a mindennapi betegell\u00e1t\u00e1s sor\u00e1n is rengeteg adatot r\u00f6gz\u00edt\u00fcnk, melyek elvben felhaszn\u00e1lhat\u00f3ak lehetn\u00e9nek arra, hogy abb\u00f3l a betegs\u00e9gek lefoly\u00e1s\u00e1r\u00f3l \u00e9s a gy\u00f3gyszerel\u00e9sek hossz\u00fat\u00e1v\u00fa hat\u00e1sair\u00f3l t\u00f6bbet megtudjunk. Sajnos jelenleg az egyetemeken haszn\u00e1lt informatikai rendszerek sem adnak alkalmas keretet tudom\u00e1nyos adatgy\u0171jt\u00e9sre. T\u00f6bb probl\u00e9ma is van, a legalapvet\u0151bb gond, hogy nagyon neh\u00e9z adatokat kinyerni ezekb\u0151l a betegell\u00e1t\u00e1sra haszn\u00e1lt szoftverekb\u0151l, a k\u00f6vetkez\u0151, hogy az eml\u00edtett rendszerek nem b\u0151v\u00edthet\u0151ek a felhaszn\u00e1l\u00f3k \u00e1ltal, nem tartalmaznak szabadon fejleszthet\u0151 adatlapokat, melyekkel a kutat\u00f3orvos maga b\u0151v\u00edthetn\u00e9 az adatbeviteli lehet\u0151s\u00e9geket. Egy ilyen rendszer haszn\u00e1lata pedig nagys\u00e1grendileg kisebb k\u00f6lts\u00e9g mellett tudna adatokat biztos\u00edtani hossz\u00fat\u00e1v\u00fa elemz\u00e9sekhez.\u00a0
\u00a0\u00a0\u00a0\u00a0 Mindez persze nem jelenten\u00e9 egy\u00e9rtelm\u0171en a hosszabb id\u0151szakot fel\u00f6lel\u0151 vizsg\u00e1latok sz\u00e1m\u00e1nak n\u00f6veked\u00e9s\u00e9t, de a mindennapi betegell\u00e1t\u00e1s sor\u00e1n sz\u00fcks\u00e9ges \u00e9s a tudom\u00e1nyos c\u00e9l\u00fa adatr\u00f6gz\u00edt\u00e9s \u00f6sszekapcsol\u00e1sa tal\u00e1n el\u00e9rhet\u0151bb\u00e9 tenn\u00e9 ezeket a vizsg\u00e1latokat.<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”In memoriam Prof. Dr. Trixler M\u00e1ty\u00e1s” url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_in_memoriam_2010dec_20110104.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_in_memoriam_2010dec_20110104.pdf” link_option_url_new_window=”on”]<\/p>\n

Fekete S\u00e1ndor<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

In memoriam Prof. Dr. Trixler M\u00e1ty\u00e1s<\/h4>\n
Fekete S\u00e1ndor<\/div>\n
\n
\n

Prof. Trixler M\u00e1ty\u00e1s emeritus egyetemi tan\u00e1r, nagyrabecs\u00fclt koll\u00e9g\u00e1nk 2010. okt\u00f3ber 23-\u00e1n, 70. \u00e9let\u00e9v\u00e9ben v\u00e1ratlanul elhunyt.\u00a0<\/p>\n

Trixler professzor egyetemi tanulm\u00e1nyait 1965-ben fejezte be kiv\u00e1l\u00f3 eredm\u00e9nnyel a P\u00e9csi Orvostudom\u00e1nyi Egyetemen, majd a v\u00e9gz\u00e9st k\u00f6vet\u0151en itt teljesedett ki szakmai munk\u00e1ss\u00e1ga. Kezdetben pszichi\u00e1ter \u00e9s neurol\u00f3gus orvosk\u00e9nt az Ideg-Elme Klinik\u00e1n dolgozott, k\u00e9s\u0151bb klinikai tev\u00e9kenys\u00e9ge egyre ink\u00e1bb a pszichi\u00e1tria ter\u00fclet\u00e9re ir\u00e1nyult. Iskolateremt\u0151 munk\u00e1t v\u00e9gzett a pszichi\u00e1triai oszt\u00e1lyok ter\u00e1pi\u00e1s strukt\u00far\u00e1j\u00e1nak \u00e1talak\u00edt\u00e1s\u00e1ban. K\u00e9t alkalommal nyert Humboldt \u00f6szt\u00f6nd\u00edjat, melynek sor\u00e1n N\u00e9metorsz\u00e1gban jelent\u0151s kutat\u00f3munk\u00e1t v\u00e9gzett. Vizsg\u00e1lati eredm\u00e9nyeib\u0151l \u00edrta kandid\u00e1tusi \u00e9rtekez\u00e9s\u00e9t. A kandidat\u00fara megszerz\u00e9s\u00e9t k\u00f6vet\u0151en oktat\u00f3i-kutat\u00f3i gy\u00f3gy\u00edt\u00f3i munk\u00e1j\u00e1t az egyetem Pszichi\u00e1triai Klinik\u00e1j\u00e1n folytatta. 1993-ban egyetemi tan\u00e1ri kinevez\u00e9st kapott, majd ugyanezen \u00e9vt\u0151l kezdve 12 \u00e9ven kereszt\u00fcl vezette a Klinik\u00e1t. Orvosk\u00e9nt, klinikusk\u00e9nt a betegek ir\u00e1nt felel\u0151ss\u00e9get \u00e9rezve v\u00e9gezte munk\u00e1jat, magatart\u00e1sa meghat\u00e1rozta a klinika arculat\u00e1t.\u00a0
\u00a0\u00a0\u00a0\u00a0 Eml\u00e9kezve Trixler professzorra, tisztelg\u00fcnk \u00e9letm\u0171ve el\u0151tt. Eml\u00e9kez\u00fcnk a form\u00e1tumos emberre, a kiv\u00e1l\u00f3 klinikusra, oktat\u00f3ra, nemzetk\u00f6zileg is j\u00f3l jegyzett kutat\u00f3ra. Nem felejtj\u00fck szakmai ki\u00e1ll\u00e1s\u00e1t, amikor a pszichi\u00e1tria szakma \u00f6n\u00e1ll\u00f3sod\u00e1sakor, az \u00f6n\u00e1ll\u00f3 identit\u00e1s\u00e9rt, l\u00e9t\u00e9rt val\u00f3 \u2013 akkor \u00e9les \u2013 k\u00fczdelemben P\u00e9csett az Ideg-Elme Klinika, a K\u00f6rnyei Iskola egyik legjobb neurol\u00f3gusak\u00e9nt tett igen sokat. V\u00e1llalta, mindenben t\u00e1mogatta az akkor sok \u00fctk\u00f6z\u00e9st kiv\u00e1lt\u00f3 \u00faj, saj\u00e1t l\u00e1b\u00e1ra \u00e1ll\u00f3 szakm\u00e1t, a pszichi\u00e1tri\u00e1t, pszichoter\u00e1pi\u00e1t. Szakmai inspir\u00e1ci\u00f3k \u00e9s tart\u00f3s bar\u00e1ts\u00e1gok alapoz\u00f3dtak abban az id\u0151szakban.\u00a0
\u00a0\u00a0\u00a0\u00a0 M\u00e1ty\u00e1s ked\u00e9lye, nyugalma, higgadts\u00e1ga, ig\u00e9nyess\u00e9ge, humora, m\u0171velts\u00e9ge p\u00e9lda marad. Eml\u00e9kezhet\u00fcnk emberi tart\u00e1s\u00e1ra a betegs\u00e9ggel szemben, j\u00f3zan, higgadt, m\u00e9rt\u00e9ktart\u00f3 viselked\u00e9s\u00e9re klinikusk\u00e9nt, oktat\u00f3k\u00e9nt, vezet\u0151k\u00e9nt a szakma v\u00e1ls\u00e1gid\u0151szakaiban is. Mind a magyar, az angol \u00e9s a n\u00e9met nyelv\u0171 orvosk\u00e9pz\u00e9sben el\u0151ad\u00e1sok \u00e9s gyakorlatok tart\u00e1s\u00e1val is r\u00e9szt vett, odaad\u00e1ssal, pontoss\u00e1ggal, magas sz\u00ednvonalon. Pszichoter\u00e1pi\u00e1s, m\u0171v\u00e9szetter\u00e1pi\u00e1s aktivit\u00e1sa nev\u00e9t igen sz\u00e9les k\u00f6rben tette ismertt\u00e9 a sz\u0171kebb orvosi szakm\u00e1n t\u00fal is. Mint\u00e1t adott nemzetk\u00f6zileg ismert kutat\u00f3k\u00e9nt, tekint\u00e9ly\u00e9vel k\u00e9pes volt munkat\u00e1rsait, de szem\u00e9lyes \u00e9lethelyzeteiben csal\u00e1dtagjait \u00e9s betegeit is v\u00e9deni neh\u00e9z helyzetekben. \u00dctk\u00f6z\u00e9sek sor\u00e1n tudott megker\u00fclhetetlen szempontokat adni, csendes f\u00f6l\u00e9nnyel, de meg\u00e9rt\u0151en \u00e9s hat\u00e1rozottan kezelni szakmai vit\u00e1kat. Munkat\u00e1rsai, csal\u00e1dtagjai t\u00e1maszkodhattak r\u00e1, tanulni tudtak t\u0151le, a szakmapolitik\u00e1ban nem tett elvtelen engedm\u00e9nyeket. K\u00e9pes volt el\u0151rel\u00e9pni \u00e9s visszal\u00e9pni is, ha kellett. Divatir\u00e1nyzatokra higgadtan reag\u00e1lva integr\u00e1lni tudta m\u00e9g a sokszor nehezen elfogadhat\u00f3 \u00faj megk\u00f6zel\u00edt\u00e9seket is a trad\u00edci\u00f3 tapasztalataival \u2013 szem\u00e9ly\u00e9t elfogadtuk, elfogadt\u00e1k, hitelesnek tartott\u00e1k m\u00e1s szakm\u00e1k is. Egyetemi vit\u00e1kban sz\u00e1m\u00edtottak higgadts\u00e1g\u00e1ra, szak\u00e9rtelm\u00e9re, jelenl\u00e9t\u00e9nek s\u00faly\u00e1ra. A genetik\u00e1t\u00f3l a klinikumig, a forenzikus pszichi\u00e1tri\u00e1t\u00f3l a m\u0171v\u00e9szetter\u00e1pi\u00e1ig mindenhez volt hozz\u00e1\u00e9rt\u0151, \u00e9rdemi mondanival\u00f3ja, oktatva, kutatva, \u00e9s publik\u00e1lva t\u00f6bb nyelven is.
\u00a0\u00a0\u00a0\u00a0 MTA doktori fokozatot 2001-ben szerzett, nemzetk\u00f6zi t\u00e1rsas\u00e1gok tagja lett, sz\u00e1mos szakmai d\u00edjat kapott, Szent-Gy\u00f6rgyi-d\u00edjat, Ol\u00e1h Guszt\u00e1v-d\u00edjat, tengerent\u00fal a Kris-dijat. Nemzetk\u00f6zi \u00e9s hazai szakmai t\u00e1rsas\u00e1gok tagjak\u00e9nt, egyetemi, klinikai vezet\u0151k\u00e9nt integr\u00e1ci\u00f3ra \u00e9s autentikus \u00e1ttekint\u00e9sre volt k\u00e9pes, j\u00f3zanul l\u00e1tva, tartva a kompetencia-hat\u00e1rokat. Konzult\u00e1ci\u00f3ra, b\u00f6lcs tan\u00e1csaira emeritus \u00e9veiben mindig sz\u00e1m\u00edthattunk.\u00a0<\/p>\n

Szem\u00e9ly\u00e9ben tan\u00edtv\u00e1nyai, munkat\u00e1rsai nagyform\u00e1tum\u00fa orvoskoll\u00e9g\u00e1t, kiv\u00e1l\u00f3 oktat\u00f3t vesztettek el.\u00a0
Eml\u00e9k\u00e9t tisztelettel \u00e9s kegyelettel meg\u0151rizz\u00fck.<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Barriers to antiviral treatment in hepatitis C infected intravenous drug users” url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_gazdag_gabor_20110104.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_gazdag_gabor_20110104.pdf” link_option_url_new_window=”on”]<\/p>\n

Gabor Gazdag, Gergely Horvath, Olga Szabo, Gabor S Ungvari<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

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 <\/p>\n<\/div>\n

\n

Background: Nowadays intravenous drug use is the main source of hepatitis C trans\u00admission, but only a small proportion of those who acquired infection via intravenous drug use receive antiviral treatment. Aim: to assess the barriers of access to antiviral treatment of infected intravenous drug users. Methods: A retrospective chart review was carried out in a hepatology outpatient clinic including all hepatitis C infected intravenous drug users in a 3-year period. Results: Only one-third of the infected former intravenous drug users received antiviral treatment. The main barrier to antiviral treatment was the lack of abstinence. Former intrave\u00adnous drug users in prison or in long-term drug rehabilitation institutes were more likely to enter antiviral treatment. Conclusions: The low proportion of patients entering antiviral treatment calls the attention to further improving the pre-treatment management of this patient population. Special attention should be paid to the maintenance of abstinence.\u00a0<\/p>\n

Keywords:<\/strong>\u00a0antiviral treatment, barriers, drug addiction, hepatitis C infection<\/p>\n<\/div>\n

\u00a0<\/h4>\n

[\/et_pb_toggle][et_pb_blurb title=”Amineptine treatment of persistent catatonic symptoms in schizophrenia: a controlled study” url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_ungvari_s_gabor_20110104.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_ungvari_s_gabor_20110104.pdf” link_option_url_new_window=”on”]<\/p>\n

Gabor S. Ungvari<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

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Background:<\/strong>\u00a0Data on the treatment response of enduring catatonic phenomena accompanying chronic schizophrenia are few and far between. The aim of this study was to explore the therapeutic effects of add-on amineptine, a dopamine agonist antidepressant in chronic catatonia occurring in schizophrenia.\u00a0Method:<\/strong>\u00a0Fifteen subjects with DSM-IV schizophrenia presenting with persistent catatonic features underwent a 15-week, double-blind, placebo-controlled cross-over trial; they were treated for 6 weeks each with amineptine and a placebo, with a 3-week wash-out period in between. The primary outcome measures were the sum scores of the Bush-Francis Catatonia Rating Scale and the Modified Rogers Scale. Changes in other aspects of psychopathology and extrapyramidal side effects (EPS) constituted the secondary outcome measures.\u00a0Results:<\/strong>Amineptine augmentation of antipsychotic treatment had no appreciable effect on either of the catatonia ratings. Apart from a statistically significant but clinically negligible improvement in the negative symptom scores, there were no changes in the psychopathology and EPS ratings.\u00a0Conclusion:<\/strong>\u00a0The lack of a therapeutic effect of the dopamine agonist amineptine on persistent catatonic signs and symptoms suggests that the dopamine system may not have a decisive role in the pathophysiology of chronic catatonic syndrome arising in the context of schizophrenia.<\/p>\n

Keywords:<\/strong>\u00a0catatonia, schizophrenia, amineptine<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Lights off? Neurobiological and pharmacological aspects of the melatonergic-serotonergic synergism” url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_sumegi_andras_20110104.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_sumegi_andras_20110104.pdf” link_option_url_new_window=”on”]<\/p>\n

Andr\u00e1s\u00a0<\/sup>S\u00fcmegi, Csilla\u00a0<\/sup>Somosk\u0151vi<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

\n

SSRI antiepressants have been widely used for treating depressive symptoms for more
than two decades. Despite their frequent usage, meta-analyses proved that only 20-25%
of the patients had achieved long term remission. The introduction and spreading of
dual-acting agents increased remission rate, but many of the patients with depressive
sypmtomps still suffer from the disorder due to partial pharmacotherapeutic efficacy.
Chronobiological disturbances might play an important role both in the pathophysiology
and in the ongoing symptoms of depression. Pathological alterations in the melatonergic
system may act as the first, obscure signs of the onset of depression. Agomelatine, a new
antidepressive agent may offer new possibilities in the pharmacotherapy of depression,
due to its synergistic melatonergic-serotonergic activity.<\/p>\n

Keywords<\/strong>: depression, agomelatine, melatonin, melatonin receptors, 5-HT2C receptor<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Trazodone \u2013 Its multifunctional mechanism of action and clinical use” url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_frecska_ede_20110104.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_frecska_ede_20110104.pdf” link_option_url_new_window=”on”]<\/p>\n

Ede Frecska<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

\n

 <\/p>\n<\/div>\n

\n

Trazodone is an antidepressant of the serotonin (5-HT2) antagonist and reuptake inhibitor
class, and has been considered to act as a multifunctional drug. It is generally approved
for the treatment of major depression, its efficacy is well-documented in elderly patients,
and it has been widely used for replacement of benzodiazepines or benzodiazepine-type
sleeping drugs due to its anxiolytic efficacy and sleep normalizing effect in depression.
Trazodone was further found to be clinically useful in generalized anxiety disorder, agitation of patients with dementia and organic disorders, chronic pain disorders, alcohol
and benzodiazepine dependence. Tolerability of trazodone is comparable to the novel
antidepressants. It is weight neutral and does not decrease sexual function. The introduction of trazodone to the Hungarian market may decrease the widespread use of
benzodiazepines in antidepressive treatment.<\/p>\n

Keywords<\/strong>: alcohol dependence, anxiety, benzodiazepine dependence, depression,
insomnia<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Etiopathology and therapy of seasonal affective disorder” url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_molnar_eszter_20110104.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/nh_2010dec_molnar_eszter_20110104.pdf” link_option_url_new_window=”on”]<\/p>\n

Eszter\u00a0<\/sup>Moln\u00e1r, X\u00e9nia\u00a0<\/sup>Gonda, Zolt\u00e1n\u00a0<\/sup>Rihmer, Gy\u00f6rgy1<\/sup>Bagdy<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

\n

To understand the etiology of seasonal affective disorder (SAD) heterogeneous biological,
psychological and environmental mechanisms needs to be considered. The aim of our
study was to review theoretical hypotheses and therapeutic possibilities for seasonal
affective disorder, which focus on alterations of circadian rhythms and monoaminergic
neurotransmitter function as well as the role of vitamin D3
and possible implications of
the cognitive-behavioral model. These discrepant hypotheses are insufficient alone to
interpret the pathophysiology of SAD, but the integrative dual vulnerability hypothesis is
an option to explain emergence of seasonal affective disorder. In addition to summarizing
theoretical approaches we also review and evaluate the therapeutic possibilities derive
form these hypotheses. In practice the most effective treatment for SAD is the combination of light therapy, antidepressants and psychotherapy.<\/p>\n

Keywords<\/strong>: seasonal affective disorder, depression, circadian rhythm, pharmacotherapy, light therapy, D3 vitamin<\/p>\n<\/div>\n

[\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/05\/Ke\u0301pernyo\u030bfoto\u0301-2019-05-29-11.57.14.png” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ box_shadow_style=”preset3″][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Volume 12, Issue 4, December 2010G\u00e1bor CsuklyAz elm\u00falt \u00e9vek sor\u00e1n a pszichi\u00e1triai t\u00e9m\u00e1j\u00fa kutat\u00e1sok \u00e9s tudom\u00e1nyos k\u00f6zlem\u00e9nyek sz\u00e1ma robban\u00e1sszer\u0171en megn\u00f6vekedett. Ahogy azt egy kor\u00e1bbi szerkeszt\u0151s\u00e9gi lev\u00e9lben olvashattuk, ilyen nagy mennyis\u00e9g\u0171 eredm\u00e9ny k\u00f6vet\u00e9se szinte lehetetlen feladat, ez\u00e9rt is n\u00f6vekszik a meta-anal\u00edzisek jelent\u0151s\u00e9ge.\u00a0\u00a0\u00a0\u00a0 Szembet\u0171n\u0151 azonban, hogy a publik\u00e1lt vizsg\u00e1latok nagyobb r\u00e9sze keresztmetszeti k\u00e9pet ad, vagy egy r\u00f6videbb […]<\/p>\n","protected":false},"author":4,"featured_media":48328,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[65],"project_tag":[],"class_list":["post-49332","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-2010-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=49332"}],"version-history":[{"count":8,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49332\/revisions"}],"predecessor-version":[{"id":49708,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49332\/revisions\/49708"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48328"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=49332"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=49332"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=49332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}