{"id":49334,"date":"2010-06-29T09:43:33","date_gmt":"2010-06-29T09:43:33","guid":{"rendered":"https:\/\/mppt.hu\/project\/2010-junius-xii-evfolyam-2-szam\/"},"modified":"2020-10-29T16:16:31","modified_gmt":"2020-10-29T16:16:31","slug":"2010-junius-xii-evfolyam-2-szam","status":"publish","type":"project","link":"https:\/\/mppt.hu\/en\/project\/2010-junius-xii-evfolyam-2-szam\/","title":{"rendered":"Volume 12, Issue 2, June 2010"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”3.22.7″ custom_padding=”||5px|||”][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n

Volume 12, Issue 2, June 2010<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”3.22.3″ custom_padding=”24px|0px|25px|0px|false|false”][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”Editoral in Hungarian ” url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/szerkesztsegi-level.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/szerkesztsegi-level.pdf” link_option_url_new_window=”on”]<\/p>\n

J\u00e1nos K\u00e1lm\u00e1n<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

Tal\u00e1n kev\u00e9sb\u00e9 ismeretes, hogy azt k\u00f6vet\u0151en, hogy Pinokki\u00f3 nevel\u0151apj\u00e1val, Dzsepett\u00f3 mesterrel k\u00f6z\u00f6sen szerencs\u00e9sen megmenek\u00fclt a c\u00e1pa bend\u0151j\u00e9b\u0151l, a T\u00fcnd\u00e9r igazi kisfi\u00fav\u00e1 v\u00e1ltoztatta a fab\u00e1b\u00fat, mivel megmentette \u00e9desapj\u00e1t \u00e9s j\u00f3l viselkedett. Ahogy cseperedett Pinokki\u00f3 \u00e9s elv\u00e9gezte a mesek\u00f6z\u00e9piskol\u00e1t, \u00fagy d\u00f6nt\u00f6tt, hogy egy helyi hi\u00e1nyszakm\u00e1t v\u00e1laszt, \u00e9s pszichi\u00e1ter lesz nagykor\u00e1ban. P\u00e1lyav\u00e1laszt\u00e1s\u00e1ban val\u00f3sz\u00edn\u0171leg jelent\u0151sen befoly\u00e1solhatta az a Carlo Collodi k\u00f6nyv\u00e9ben is eml\u00edtett kora gyermekkori traumatikus \u00e9lm\u00e9nye, hogy miut\u00e1n nem hallgatott a Sz\u00f3l\u00f3 T\u00fccs\u00f6kre \u00e9s nem ment haza id\u0151ben, bizonyos gyilkosok felakasztott\u00e1k \u0151t a V\u00f6r\u00f6s R\u00e1k fogad\u00f3n\u00e1l. M\u00e9g szerencse, hogy a K\u00e9k Haj\u00fa L\u00e1nyka megmentette szeg\u00e9ny Pinokki\u00f3 \u00e9let\u00e9t, hiszen h\u00e1rom orvost is hivatott hozz\u00e1, hogy megtudja \u00e9l-e, hal-e? A h\u00e1rom b\u00f6lcs orvos term\u00e9szetesen nem \u00e9rtett egyet, \u00e9s \u00edgy nem is tudta eld\u00f6nteni, hogy Pinokki\u00f3 \u00e9l, vagy esetleg meghalt. Mindenesetre azt javasolt\u00e1k a T\u00fcnd\u00e9rnek, hogy szedessen vele orvoss\u00e1got. A b\u00e1bu azonban \u201ecs\u00f6kkent ter\u00e1piah\u0171s\u00e9ggel\u201d reag\u00e1lt a javaslatra \u00e9s m\u00e1r kezdett\u0151l fogva nem akarta a javasolt gy\u00f3gyszereket beszedni. De el\u00e9g is a m\u00faltb\u00f3l, azaz Pinokki\u00f3 orvoss\u00e1 v\u00e1l\u00e1s\u00e1nak motiv\u00e1ci\u00f3s t\u00e9nyez\u0151ib\u0151l, ford\u00edtsuk ink\u00e1bb figyelm\u00fcnk h\u0151s\u00fcnk feln\u0151ttkori sors\u00e1ra, azaz arra, hogy milyen kalandok \u00e9rt\u00e9k \u0151t gyakorl\u00f3 pszichi\u00e1terk\u00e9nt.
\u00a0\u00a0\u00a0\u00a0 Pinokki\u00f3 doktor rezidensi \u00e9vei let\u00f6lt\u00e9se ut\u00e1n lelkes, szorgalmas szakorvoshoz ill\u0151en folyamatosan seg\u00edtette betegeit, akik t\u00f6bbnyire kor\u00e1bbi falubeli ismer\u0151sei k\u00f6z\u00fcl ker\u00fcltek ki. Itt volt p\u00e9ld\u00e1ul R\u00e9zorr mester, aki m\u00e9g fadarab form\u00e1j\u00e1ban tal\u00e1lta meg \u0151t \u00e9s most alkoholfogyaszt\u00e1si probl\u00e9m\u00e1i miatt fordult Pinokki\u00f3 doktorhoz. De betegei k\u00f6z\u00e9 tartozott maga Dzsepett\u00f3 is, azaz nevel\u0151apja, akin\u00e9l az id\u0151 m\u00fal\u00e1s\u00e1val a vascularis demencia diagn\u00f3zis\u00e1t \u00e1llap\u00edtotta meg. Sz\u00f3l\u00f3 T\u00fccs\u00f6k urat pedig kor\u00e1bban k\u00e9nyszerbetegs\u00e9ggel, majd egy sajn\u00e1latos baleset ut\u00e1n – fakalap\u00e1ccsal fejbevert\u00e9k – organikus pszichoszindr\u00f3m\u00e1val kezelte. Kev\u00e9sb\u00e9 n\u00e9pszer\u0171 betegei k\u00f6z\u00e9 tartozott R\u00f3ka \u00e9s Kand\u00far \u00far, akikn\u00e9l disszoci\u00e1lis szem\u00e9lyis\u00e9gvon\u00e1sokat v\u00e9lt felismerni. \u00d6r\u00f6kk\u00e9 pajkos, soha fel nem n\u00f6v\u0151 bar\u00e1tja, Kan\u00f3c pedig figyelemzavar, hiperaktivit\u00e1s feln\u0151ttkori probl\u00e9m\u00e1ival j\u00e1rt kezel\u00e9sre hozz\u00e1.
\u00a0\u00a0\u00a0\u00a0 A lelkiismeretes Pinokki\u00f3 doktornak munk\u00e1ja sor\u00e1n azonban egyre t\u00f6bb probl\u00e9m\u00e1ja jelentkezett az orra m\u00e9reteivel. Azt vette \u00e9szre ugyanis, hogy ha igyekezett megfelelni Meseorsz\u00e1g eg\u00e9szs\u00e9g\u00fcgyi rendelkez\u00e9seinek \u00e9s Meseorsz\u00e1g mes\u00e9s t\u00e1rsadalombiztos\u00edt\u00e1si szab\u00e1lyainak, akkor folyamatosan n\u0151tt az orra. Azaz, ahhoz hogy betegeinek bizonyos gy\u00f3gyszereket fel tudjon \u00edrni, vagy javasolni tudjon, olyan diagn\u00f3zisokat kellett adnia Meseorsz\u00e1g t\u00e1rsadalombiztos\u00edt\u00e1si szab\u00e1lyai szerint, amelyek azonnali orrny\u00fal\u00e1st garant\u00e1ltak sz\u00e1m\u00e1ra. Az is el\u0151fordult n\u00e9ha, hogy betegei k\u00f6z\u00fcl pszichi\u00e1triai oszt\u00e1lyra kellett felvenni n\u00e9melyiket. Ezekben az esetekben is szinte biztos lehetett abban, hogy ism\u00e9telten n\u00f6vekszik az orra, hiszen az \u00e1pol\u00e1si napokhoz kellett diagn\u00f3zisokat v\u00e1lasztania, \u00e9s vica-versa. De az is el\u0151fordult, \u00e9s ez is az orra rov\u00e1s\u00e1ra ment, hogy csak addig tarthatta betegeit az oszt\u00e1lyon, am\u00edg Meseorsz\u00e1g \u00e1pol\u00e1si napjai engedt\u00e9k. Ennek megfelel\u0151en Pinokki\u00f3 doktor orra csak n\u0151tt \u00e9s n\u0151tt,\u00a0
\u00e9s h\u0151s\u00fcnk nem igaz\u00e1n \u00e9rtette, hogyan v\u00e1ltoztathatna helyzet\u00e9n. Tudta, hogy ha nem k\u00f6veti Meseorsz\u00e1g eg\u00e9szs\u00e9g\u00fcgyi szab\u00e1lyait, a hat\u00f3s\u00e1gok \u201eorrolnak\u201d meg r\u00e1, ha pedig k\u00f6veti a szab\u00e1lyokat, akkor a betegei v\u00e1ghatj\u00e1k orrba, mert nem igaz\u00e1n \u00e9rzik, hogy seg\u00edtene rajtuk. A buridi\u00e1ni dilemma miatt l\u00f3gatta is az orr\u00e1t Pinokki\u00f3 doktor \u00e9ppen eleget. \u00a0
\u00a0\u00a0\u00a0\u00a0 F\u0151n\u00f6ke l\u00e1tta helyzet\u00e9t (odafigyelt r\u00e1, hiszen m\u00e1s oszt\u00e1lyos orvosa nem is volt) \u00e9s m\u00e9lyen \u00e1t\u00e9rezte Pinokki\u00f3 doktor szomor\u00fas\u00e1g\u00e1t, ez\u00e9rt arra gondolt, hogy megpr\u00f3b\u00e1lja felvid\u00edtani. Kezdetben a Mesekamara seg\u00edts\u00e9g\u00e9vel k\u00f6zvet\u00edtett \u00d3perenci\u00e1s tengeren t\u00fali pszichi\u00e1ter \u00e1ll\u00e1saj\u00e1nlatokat mutatott neki kacsal\u00e1bon forg\u00f3 h\u00e1zakkal \u00e9s kir\u00e1lykisasszonyokkal. K\u00e9s\u0151bb \u00fagy pr\u00f3b\u00e1lt siker\u00e9lm\u00e9nyt adni kedvenc szakorvos\u00e1nak, hogy arra k\u00e9rte, \u00edrjon egy rangos tudom\u00e1nyos k\u00f6zlem\u00e9nyt a Neuropszichopharmacologia Hungaric\u00e1ba saj\u00e1t farmakoter\u00e1pi\u00e1s tapasztalatair\u00f3l. Nagyon meg\u00f6r\u00fclt Pinokki\u00f3 doktor, hogy v\u00e9gre megmutathatja Dzsepett\u00f3 pap\u00e1nak, illetve koll\u00e9g\u00e1inak Meseorsz\u00e1gban \u00e9s az \u00d3perenci\u00e1s tengeren t\u00fal is, hogy milyen \u00fcgyesen kezeli betegeit. Fogta \u00e9s belevetette mag\u00e1t sz\u00e1m\u00edt\u00f3g\u00e9pes adatb\u00e1zis\u00e1ba \u00e9s teljesen megfeledkezett az\u00f3ta is riaszt\u00f3 m\u00e9rt\u00e9kben n\u00f6veked\u0151 orr\u00e1r\u00f3l. Lelkesen kezdte elemezni Meseorsz\u00e1g t\u00e1rsadalombiztos\u00edt\u00e1sa szerint nyilv\u00e1ntartott betegei adatait, de k\u00f6zben r\u00e1j\u00f6tt, hogy abba kell hagynia ezt a munk\u00e1t is, mert m\u00e1r nem f\u00e9rt be a dolgoz\u00f3szob\u00e1j\u00e1ba az orr\u00e1t\u00f3l. Sem farmakoepidemiol\u00f3giai, sem nyomonk\u00f6vet\u00e9ses naturalisztikus ter\u00e1pi\u00e1s hat\u00e1svizsg\u00e1latokat, de m\u00e9g szindromatol\u00f3giai alcsoport elemz\u00e9seket sem tudott v\u00e9gezni. S\u0151t, m\u00e9g farmakogenomikai vizsg\u00e1latokra \u00e9s epigenetikai hat\u00e1selemz\u00e9sekre sem tudta felhaszn\u00e1lni var\u00e1zslatos mennyis\u00e9g\u0171 mese-t\u00e1rsadalombiztos\u00edt\u00e1si adatait, mert a sz\u00e1mok sehogy sem stimmeltek \u00e9s nem t\u00fckr\u00f6zt\u00e9k az \u00e1ltala ismert val\u00f3s\u00e1got. \u00cdgy nem meglep\u0151, hogy minden elemz\u00e9si k\u00eds\u00e9rlet\u00e9nek csak ism\u00e9telt orrn\u00f6veked\u00e9s lett az eredm\u00e9nye. A v\u00e9g\u00e9n m\u00e1r ott tartott, hogy m\u00e1r a sz\u00e1m\u00edt\u00f3g\u00e9p\u00e9nek az orra is n\u0151ni kezdett. Pinokki\u00f3 doktor ekkor azt\u00e1n fogta mag\u00e1t \u00e9s abbahagyta a tudom\u00e1nyoskod\u00e1st. Megfogadta, hogy t\u00f6bb\u00e9 nem \u00fcti bele az orr\u00e1t ilyen dolgokba \u00e9s nem hogy a Neuropszichopharmacologia Hungaric\u00e1ba, de m\u00e9g a New Disneyland Journal of Medicine-be sem fog egy \u00e1rva kukkot sem k\u00f6z\u00f6lni. Elhat\u00e1roz\u00e1sa f\u0151n\u00f6k\u00e9t is igen elszomor\u00edtotta, akinek amb\u00edci\u00f3i a mesetudom\u00e1nyok nagydoktora c\u00edm megszerz\u00e9s\u00e9r\u0151l ez\u00e1ltal k\u00f6dd\u00e9 v\u00e1ltak, \u00e9s m\u00e1r csak az aranyhallal, mint m\u00e9diummal folytatott, h\u00e1rom k\u00edv\u00e1ns\u00e1gos, parapszichol\u00f3giai k\u00eds\u00e9rleteinek publik\u00e1l\u00e1s\u00e1ban rem\u00e9nykedhetett.\u00a0
\u00a0\u00a0\u00a0\u00a0 Term\u00e9szetesen mindannyian tudjuk, hogy Pinokki\u00f3 doktor t\u00f6rt\u00e9nete csak mese \u00e9s ilyen, validit\u00e1si probl\u00e9m\u00e1kkal k\u00fcszk\u00f6d\u0151 eg\u00e9szs\u00e9g\u00fcgyi nyilv\u00e1ntart\u00e1s csak Meseorsz\u00e1gban l\u00e9tezhet. Nek\u00fcnk szerencs\u00e9re nincsen sz\u00fcks\u00e9g\u00fcnk T\u00fcnd\u00e9rekre, hogy seg\u00edtsenek orrunk megr\u00f6vid\u00edt\u00e9s\u00e9ben\u2026 \u00e9s a Neuropszichopharmacologia Hungaric\u00e1ban is folyamatosan jelennek meg hazai eg\u00e9szs\u00e9g\u00fcgyi adatb\u00e1zisokra t\u00e1maszkod\u00f3 klinikai farmakol\u00f3giai elemz\u00e9sek. Vagy tal\u00e1n nem?<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Development of Depression Profile: a new psychometric instrument to selectively evaluate depressive symptoms based on the neurocircuitry theory” url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/depresszio-profil-egy-uj-mereszkoez-a.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/depresszio-profil-egy-uj-mereszkoez-a.pdf” link_option_url_new_window=”on”]<\/p>\n

Gabor Faludi, Xenia Gonda, Edit Kliment, Vera Bekes, Veronika Meszaros, Attila Olah<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

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Background:<\/strong>\u00a0Although we have several self-report instruments available to assess depression, they yield a composite score and thus do not allow for the differential examination of major symptom clusters associated with depression. However, such an instrument would be a useful tool in subtyping depression and selecting the most appropriate pharmacotherapy for each patient. The neurocircuitry theory describes the biochemical and neuroanatomic background associated with the major symptoms of depression. Based on the neurocircuitry theory, our team has developed a new instrument, the Depression Profile, to selectively assess depressive symptom clusters associated with different neurotransmitter systems and neuroanatomic structures. The aim of our study was to investigate the psychometric characteristics of Depression Profile.\u00a0Methods:<\/strong>\u00a0339 patients consecutively admitted with DSM-IV major depression in our hospital completed the Depression Profile in the first two weeks of their hospitalisation. 81 patients in an adult outpatient unit also completed the Zung Self-rating Depression Scale. Internal consistency of Depression Profile was tested with item analysis. The external validity of Depression Profile against the Zung Self-rating Depression Scale was tested using Pearson correlations.\u00a0Results:<\/strong>\u00a0The internal consistency of Depression Profile proved to be excellent. The Cronbach alpha values of the scales met the expectable minimum level derived from the number of items in the scales. In testing for convergent validity, all Pearson correlation coefficients between Depression profile subscales and the Zung Self-rating Depression Scale were significant and moderate to high which indicates the good external validity of our instrument.\u00a0Discussion:<\/strong>\u00a0The initial psychometric evaluation of Depression Profile indicates that our instrument has good reliability and internal and external validity. The instrument also proved to be useful in clinical work to aid the choice of medications and determine the subtype of depressive episodes. Further studies, possibly with biochemical and neuroimaging methodology are needed to validate the 9 main symptom clusters of the Depression Profile subscales with respect to their neuroanatomical and neurochemical bases.\u00a0<\/p>\n

Keywords:<\/strong>\u00a0depression, psychometric validation, depressive symptoms, neurocircuitry theory<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Serotonin transporter gene and threatening life events are associated with depressive phenotype” url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/serotonin-transporter-gene-and-threatening-life.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/serotonin-transporter-gene-and-threatening-life.pdf” link_option_url_new_window=”on”]<\/p>\n

Judit Lazary<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”4.6.6″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

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\u00a0Although heritability of affective disorders is well accepted, several questions are still unsolved. The phenotype associated with the disorder is still uncertain, e.g., different disorders of the affective spectrum could be observed in the family of the patient. Furthermore, genetic studies failed to provide exact explanation for these questions either. We reported first that the role of the promoter region variant (5-HTTLPR) is not exclusive, and the middle region (tagged by the SNP rs140700) of the gene has also a significant role in the G x E model. Furthermore, we discovered a significant Gene x Gene x Environment interaction between 5-HTTLPR, rs140700 and threatening life events. Haplotype analyses of the serotonin transporter gene suggested that the majority of the S allele carriers for 5-HTTLPR with multiple threatening life events expressed high depression score, however, a subgroup with much lower depression score was also identified. In another study, interaction of 5-HTTLPR with the cannabinoid receptor 1 gene promoter was significantly associated with anxious phenotype. These results suggest that extremely high or low synaptic serotonin concentration could be associated with a high anxiety score. These findings call attention to the serotonergic dysfunction in the vulnerability for affective disorders.<\/p>\n<\/div>\n

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Keywords:<\/strong>\u00a05-HTTLPR, gene-environment interaction, threatening life events, cannabinoid receptor, affective disorders<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Sense and sensibility: Bipolar affective disorder as a battlefield of cognitions and emotions \u2013 lamotrigine therapy as a peacekeeper” url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/ertelem-es-erzelem-a-bipolaris-affektiv.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/ertelem-es-erzelem-a-bipolaris-affektiv.pdf” link_option_url_new_window=”on”]<\/p>\n

J\u00e1nos K\u00e1lm\u00e1n and J\u00e1nos Jr. K\u00e1lm\u00e1n\u00a0<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

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The cortico-limbic dysregulation theory of bipolar affective disorder (BAD) is supported
by ample of recent research evidences. This concept is based on the dysharmonic regulation of prefrontal and anterior limbic structures manifested in a strong interaction of
cognitive and affective symptoms. The major aim of the present review is to characterize the BAD specific cognitive profile and to describe the cognitive syndrome of BAD
during the natural course of the disorder, based on recent findings in neurobiology,
neuropathology, neuroradiology, cognitive psychology and neurogenetics. The authors
recommend that BAD-associated cognitive symptoms should always be considered during the recognition, follow up and treatment phases of the disorder. The importance of
the cognitive syndrome is also emphasized from the aspects of outcome and existing
therapeutic regimens of the disorder. The cognitive syndrome-associated perspective
of BAD could therefore provide new approaches regarding the long-term management
issues of patients. Evidence from recent clinical trials is also summarized regarding the
interactions of existing BAD treatment options with cognitive symptoms of the disorder,
since all of the recommended antipsychotics and antiepileptics have a certain degree of
cognitive toxicity. Based on the overview of the existing clinical trials, it was concluded
that lamotrigine has the smallest cognitive toxicity among the mood stabilizers used for
the treatment of BAD type-2. Therefore, as far as the cognitive toxicity profile is concerned,
lamotrigine is recommended as the most promising therapeutic approach both for the
treatment of bipolar depressive phases and relapse prevention. In addition, neuroprotective properties of the same molecule might also be beneficial regarding the proposed
pathomechanism of BAD.<\/p>\n

Keywords<\/strong>: bipolar affective disorder, cognitive symptom, mood stabilizer, lamotrigine<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”Long-term (prophylactic) therapy of bipolar patients with aripiprazole” url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/bipolaris-betegek-hosszutavu-profilaktikus-kezelese-aripiprazollal.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/bipolaris-betegek-hosszutavu-profilaktikus-kezelese-aripiprazollal.pdf” link_option_url_new_window=”on”]<\/p>\n

G\u00e1bor Kov\u00e1cs<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

\n

This case report presents two female bipolar patients, suffering from their disorders
for several years, who are now on prophylactic aripiprazole therapy. Previously given
drugs were ineffective and\/or caused side effects, so the therapy had to be changed.
The patients are now on aripiprazole for two years without any affective episodes, their
functioning is appropriate and there has been no need for hospitalization. The condition
of the first patient has been balanced by aripiprazole-venlafaxine combination therapy.
The second patient was first prescribed aripiprazole and lithium, but because of its side
effect (hypothyreosis), lithium has been stopped after six months, so she is on aripiprazole monotherapy for one and a half year. The initial dose of aripiprazole was 15 and
30 mg for the two patients, which caused extrapyramidal side effects, disappearing after
changing to a maintenance dose of 7.5 mg. Unfortunately at present no specific clinical
or biological markers are available for clinicians to guide their choice of medications.
The two cases presented raises attention not only to the success of aripiprazole prophylactic treatment, but also to several factors which in the future may aide the clinician in
choosing the adequate pharmacological agent (gender, bipolar I disorder, psychotic mixed
episodes, partial remission during interepisodes, effectiveness of low dose aripiprazole).<\/p>\n

Keywords<\/strong>: aripiprazole, bipolar disorder, prophylactic therapy<\/p>\n<\/div>\n

[\/et_pb_toggle][et_pb_blurb title=”The use of aripiprazole in the treatment of catatonia” url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/az-aripiprazol-alkalmazasa-katatoniaban.pdf” url_new_window=”on” image=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/04\/pdf.png” icon_placement=”left” image_max_width=”105%” content_max_width=”1100px” _builder_version=”3.22.7″ header_font=”||||||||” header_font_size=”17px” header_line_height=”1.3em” body_font=”||on||||||” body_line_height=”1.3em” link_option_url=”https:\/\/mppt.hu\/magazin\/pdf\/xii-evfevfolyam-2-szam\/az-aripiprazol-alkalmazasa-katatoniaban.pdf” link_option_url_new_window=”on”]<\/p>\n

Viktor\u00a0 V\u00f6r\u00f6s and Tam\u00e1s T\u00e9nyi<\/p>\n

[\/et_pb_blurb][et_pb_toggle title=”Abstract” closed_toggle_text_color=”#000000″ closed_toggle_background_color=”rgba(0,0,0,0)” icon_color=”#0c71c3″ _builder_version=”3.22.7″ title_font=”|600|||||||” title_letter_spacing=”1px” text_orientation=”justified” custom_padding=”0px||10px” border_width_all=”0px” border_width_bottom=”1px”]<\/p>\n

\n

Introduction: Successful aripiprazole treatment of catatonia was reported in some recent
case reports. Method: Review of the literature and three case reports. Results: In the
presented cases it was demonstrated that aripiprazole was effective in the treatment of
catatonia in patients with schizophrenia, major depression or brief psychotic disorder.
Conclusion: Besides benzodiazepines and electroconvulsive therapy, aripiprazole might be
an alternative treatment for catatonia, however randomized controlled trials are required
to prove the effectiveness of aripiprazole in patients with catatonia.<\/p>\n

Keywords<\/strong>: aripiprazole, catatonia, case report<\/p>\n<\/div>\n

[\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/mppt.hu\/wp-content\/uploads\/2019\/05\/cimlap-jun-2010-218×308.jpg” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ box_shadow_style=”preset3″][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Volume 12, Issue 2, June 2010J\u00e1nos K\u00e1lm\u00e1nTal\u00e1n kev\u00e9sb\u00e9 ismeretes, hogy azt k\u00f6vet\u0151en, hogy Pinokki\u00f3 nevel\u0151apj\u00e1val, Dzsepett\u00f3 mesterrel k\u00f6z\u00f6sen szerencs\u00e9sen megmenek\u00fclt a c\u00e1pa bend\u0151j\u00e9b\u0151l, a T\u00fcnd\u00e9r igazi kisfi\u00fav\u00e1 v\u00e1ltoztatta a fab\u00e1b\u00fat, mivel megmentette \u00e9desapj\u00e1t \u00e9s j\u00f3l viselkedett. Ahogy cseperedett Pinokki\u00f3 \u00e9s elv\u00e9gezte a mesek\u00f6z\u00e9piskol\u00e1t, \u00fagy d\u00f6nt\u00f6tt, hogy egy helyi hi\u00e1nyszakm\u00e1t v\u00e1laszt, \u00e9s pszichi\u00e1ter lesz nagykor\u00e1ban. P\u00e1lyav\u00e1laszt\u00e1s\u00e1ban […]<\/p>\n","protected":false},"author":4,"featured_media":48325,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[65],"project_tag":[],"class_list":["post-49334","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-2010-en"],"_links":{"self":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/comments?post=49334"}],"version-history":[{"count":5,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49334\/revisions"}],"predecessor-version":[{"id":49719,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project\/49334\/revisions\/49719"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media\/48325"}],"wp:attachment":[{"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/media?parent=49334"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_category?post=49334"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/mppt.hu\/en\/wp-json\/wp\/v2\/project_tag?post=49334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}